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Great that the investigators didn't stop at investigating the proteomics in the Zurich cohort after reassessing with the demographics properly taken into account, but also looked at two cohorts of their own: people post-severe Covid and people post-mild Covid. Regarding that last cohort, the...

Thanks for posting @SNT Gatchaman, looks interesting, and a lesson in the need to match cohorts.

Chris Ponting's response to the NIH study, as set out there in the discussion with David, is spot on. The study is too small to produce useful results; and there are unwarranted interpretations of the meagre data that is there. It's a disappointment. Chris hints that the mediocre nature of the...

Interpreting BOLD: towards a dialogue between cognitive and cellular neuroscience some background on BOLD signals in fMRI - although a 2016 paper

Not to take away from the urgent need for better management of people with very severe ME/CFS, and hoping not to distract the conversation, but: I just wanted to note that CBT and other interventions based on a belief that ME/CFS is psychosomatic and can be overcome if the person is diligent...

A helpful, sympathetic interview, it's not long, the transcript doesn't take long to read. Here's a key bit of the transcript:

And, that sentence rings alarm bells for me for the opposite reason. We don't know the etiopathology of Longcovid. We know what appears to be the inciting illness, sure, but we know that for a whole range of ME/CFS cases e.g. EBV infection. Still, perhaps their discussion about muscles will be...

As a reminder of what Peter Gladwell's years of providing care to people with ME/CFS have led him to believe about good clinical services, the AfME Pacing booklet provides a good insight. 'Pacing for people with M.E.' Action for ME booklet - revised and updated January 2020. In that thread...

The aim of the study is to produce a "clinical assessment toolkit", one that can be used in clinical care, but also in the evaluation of both existing and new services. And yet, Sarah Tyson seems to refuse to accept that objective measures need to be a core part of the clinical assessment...

Sounds very good @SNT Gatchaman. That loss of power that happens sometimes really does feel like inadequate oxygen, it's just like what happens at high altitude. I see you found the paper in this thread - another one of those studies done decades ago. Impaired oxygen delivery to muscle in...

Mean number of steps/day = 5679 SD 3332 (sic) (Sorry, I've run out of steam)

Thanks to a member for access. A Turkish team So, the question I have is how relevant is this to ME/CFS type illness. In the introduction the authors seem to be suggesting that the long-term (ME/CFS-type) symptoms are associated with ground glass opacities in the lungs. Uses a measure of...

Not even proof of that. The main PACE trial paper shows that 160 people were in the GET group at baseline, at 24 weeks there were only 150. I assume you are talking about differences in fatigue as measured by the Chalder Fatigue Questionnaire and physical function as measured by the SF-36...

I don't think they are looking for detailed rationales. Maybe just a suggestion and a sentence or two and a link to one or two relevant papers as background?

My grandfather was gassed in WW1 and suffered long term health problems following the event. Although, I should add, he was a lovely man with no psychological issues that I was aware of, remarkable really considering what he went through. His diaries of the war recount times when people were...

I know. After seeing Eddie's much more accomplished effort, I suddenly became concerned that I had misunderstood SNT's post, and that he had also made a picture up for our entertainment. So I actually had to click through to the paper to see. And there it was in all its awfulness. And even...

Yep, that picture gets my vote for the S4ME 'most inane illustration of the year' award. Seriously? This is from a cardiovascular medicine expert from Stanford? What, is this some new germ theory where it's possible to outrun the virus? Or confuse it, by constantly zigzagging? Let's forget...

and for background reading: ______ Lipid Droplets and the Management of Cellular Stress, 2019 Abstract Lipid droplets are cytosolic fat storage organelles present in most eukaryotic cells. Long regarded merely as inert fat reservoirs, they are now emerging as major regulators of cellular...

please do

I'm not sure about putting it out on twitter, I'm not sure about their capacity to cope with lots of submissions. Maybe just leave it here? Or, contact Vicky to clarify?