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https://www.nature.com/articles/s41598-020-61381-9#Fig1 Doxycycline has anti-tumour effects in a range of tumour systems. The aims of this study were to define the role mitochondria play in this process and examine the potential of doxycycline in combination with gemcitabine. We studied the...

:) I was quite happy with that, glad you noticed.

Disordered thinking is a symptom, and can be caused by a range of things, in the same way that fatigue or headache are symptoms that can be caused by many things. It makes sense to have some doctors who are really good at diagnosing conditions from a main symptom, or from a range of symptoms...

It's a great article, thanks for posting it @Gradzy. Well done to Dr Tim Ubhi. The boy and his parents must have gone through hell during those 3 years when his symptoms were being labelled as FND. The thought of more parents and children going through that, it's horrendous. There are...

I think this is right. If doctors who specialise diseases of the brain/central nervous system are neurologists, then a lot of illnesses with psychiatric symptoms should be managed by them. Perhaps, as there is more knowledge, the subspecialties will be divided up less by the outward symptoms...

You are right, it is better than some approaches; there is recognition of PEM. However, there's the issue of whether it is sensible for money to be allocated to these "individualised treatments". I don't think there is any good evidence that the rehabilitation approaches, for both people with...

Just to argue with myself, I note that the reference #70 above in the quote in my post above is from a 2017 paper, which itself is quoting a 2013 paper: The 2017 paper, by Christopher Ecclestone and Geert Crombez, is a muddle of useful observations like the one quoted above and all of the...

That's a lovely article @Mike Harley. I found it very moving.

I don't disagree @rvallee, but, from that very low bar, this is progress. It's not nothing.

The authors appear to have partially understood the enormous bias that comes from subjective outcomes in unblinded trials, especially where the treatment aims to reduce the importance participants attribute to the symptoms being measured as outcomes. But when it comes to recommendations for...

Lots of interesting points in the discussion- here are some: Cochrane reviews have a special place in the assessment of the clinical efficacy of interventions, because they concentrate on methodological issues designed to reduce the impact of bias. For pain-related topics, most forms of bias...

BPS approaches are getting a bit of a blitzing lately, with that spinal pain paper finding many flawed studies, that affected the findings of reviews and guidelines that based recommendations on them. Cochrane seems to be part of this improvement. Systematic review quality assessment...

I have seen some reports on the forum of psychiatrists being helpful, and we do have some psychiatrists as members. I think though, that while there may have been a valid role for psychiatrists, that role is rapidly shrinking. Biological: As knowledge of the diseases that cause problems with...

Yes, intravenously.

So, a painful dental operation - Patients were told that they might receive either morphine ('a powerful analgesic'), placebo, or naloxone (which might increase their pain). There was blinded administration of naloxone and a placebo. It says that patients given morphine were excluded from the...

Ictal injuries seem to be injuries caused by seizures e.g. tongue biting, bruising. I haven't read the study, but from the abstract, it looks to be simply concluding that the fact that someone is injured by their seizure doesn't mean it's not psychosomatic.

Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases, 2022 ( a review) Looks as though there are a number of human trials of TUDCA in neurodegenerative diseases underway.

A large part of that is a product of BPS attitudes. People who could help fund raise and be ambassadors are ashamed to be associated with ME/CFS. And many families and friends turn away from people with ME/CFS, also feeling the shame and not wanting to facilitate false illness beliefs. People...

Thanks for highlighting that bit SNT. I think that's useful wording to suggest in the 'Language' section of the UK Consultation on the ME/CFS Delivery Plan. Link here: 5. UK: 2023 Interim Delivery Plan on ME/CFS consultation: Language use

I guess the issue is, are the viruses latent in cells, in a form where DNA/RNA is not being shed into easily accessible samples? I was reading something about the measles virus that can sit in brain cells for years and then cause encephalitis. It seemed to spread by causing cells to fuse...