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Abstract Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of the infecting Borrelia burgdorferi spirochete, but the microbial genetic elements underlying these associations are not known...

With the benefit of a night's sleep, they seem to be saying this, for example for central venous pressure Supine central venous pressure - 8.6 cm H2O when first supine, increasing to a maximum of 12.6 cm H2O during the headdown tilt, but then returning to baseline over the 20 hours spent in the...

There's a paywall, so I can't check. I find the results given in the abstract a bit unclear. What parameters remained altered after the 20 hours of bedrest, and how long did they stay altered?

I don't think there is much in the way of a benefit beyond a short term placebo effect and possibly some natural improvement with time. Figure 2a shows the mean SF36-Physical function scores for the 10 participants at baseline, and the three following months. Figure 2b shows individual SF-36...

As they did for the pre-Covid studies, they selected people with ME/CFS and elevated ADRB2 autoantibodies. So, this is a subset of people with post-Covid ME/CFS. 10 participants This regime is similar to that used for the two pre-Covid studies. Those studies also used 5 IA treatments...

Long version Plain language version Seems like some result inflation going on here. And the finding that aromatherapy, massage and acupressure relieve fatigue surely should be casting doubt on all of the studies with similar methodologies.

So, they note they previously conducted a preliminary study in people with ME/CFS, and they say that seven out of ten of the patients responded rapidly - here are references 10 and 11: Here's the forum thread for Ref 11: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat...

Results Levels of IgG and of autoantibodies decreased during the treatment period. Regarding IA1- 2018 and the long lasting improvements - only some of the ten patients seemed to improve in the short term. Two years later, the status of 5 'responders' was that, compared to the baseline before...

Participant selection The 5 participants were regarded as responders to a previous trial of the therapy (IA1 in 2018). And all of the participants had increased B2AR-ABs. So, this is not a random sample. That's ok, but something to keep in mind. Treatment The treatment in IA1-2018 was 5...

Reading those reviews of Paul Jenkins, I do feel a little bit of sympathy for any doctor specialising in ME/CFS. A lot of patients expect to be helped, specially if they are seeing the doctor privately, and so are very disappointed if all they get is a diagnosis. That will be especially true...

I'm very hopeful that ME/CFS will be better understood and that understanding will result in treatments. And I do think that the work on Long Covid and the economic imperative of getting so many working age people productive again will contribute to that. There are so many people now demanding...

I disagree that the psychosomatics debate isn't that relevant to ME/CFS, or that the UK is an exception. In my country, I would bet on most doctors thinking that health anxiety/hypochondria/conversion disorder is a substantial part of ME/CFS. It's the same across the world, I know it's the...

More acclaim for this video: Suggestions of info to send a naturopath that sees a lot of ME patients and is also is educating other naturopath students?

Ha, yes, if only. Where's the down-side? You make the claims and, in the unlikely event that someone complains and the ASA (or equivalent depending on your country) decides the ad is misleading, you just say, 'oh sorry, we know the treatment helps, we just didn't realise how much evidence is...

There's lots to think about in this paper. One is how variable exosome contents are before, during and after exercise (see Figure 5). It means that any study of them has to really carefully control for exertion. I wonder how long exosomes last and if there is variation diurnally and also with...

There's a nice summary of work done on EVs in ME/CFS in the paper: Eguchi study link: Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers...ME/CFS 2019, Eguchi et al. Edit - having just read through the thread for that...

A brief item on Radio New Zealand https://www.rnz.co.nz/national/programmes/morningreport/audio/2018904918/nz-s-only-long-covid-clinic-to-shut It has a GP saying that they are seeing a lot of Long Covid patients and they don't know what to do with them and that they aren't funded to look after...

That's so interesting @rvallee. I only heard about this phenomenon recently, in relation to the persistence of the measles virus in the brain. The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome, 2023, Maureen R. Hanson Definitely, this is an area that needs more research.

Use of sildenafil (viagra) to alter fatigue, functional status and impaired cerebral blood flow in ... CFS, 2020, Friedman (Pfizer) There was that study, which possibly found some benefit, but there were a lot of problems, and so it ended up being a bit of a mess.

Thank you to the family for the fundraising and for publicising ME/CFS.