Search results

Oh, for sure, they have their cake, eat it too, and still manage to package it up and present it as a health food that's a gift to mankind... It can be both life's stoics who can't complain even to themselves who are most at risk while at the same time it's the attention-seeker who is making a...

This is a 2015 paper. I think there has been some evolution on the thinking about whether a history of emotional trauma is necessary, or even if psychological conflict and repression of feelings is necessary. I think that evolution was necessary because studies just did not support those...

So Cork study - 20 recovered, 20 PASC 'serotonin was among the metabolites whose abundance was most strongly depleted in PASC Sadlier et al. Metabolic rewiring and serotonin depletion in patients with postacute sequelae of COVID-19. Allergy. 2022; Forum thread here: Metabolic rewiring and...

Here's the chart of serotonin. Controls on the left in blue, then PASC at T1 and T2. I find this less than convincing as evidence for a serotonin deficiency in PASC. I think the median values for controls and PASC probably aren't very different. There are some individuals with extremely low...

https://onlinelibrary.wiley.com/doi/10.1111/all.15253 Letter, open access Cork study Serum was obtained from PASC patients (n = 20) at two time points (4–6 months following infection (T1) and 6–9 months following infection (T2)). All patients had been hospitalized for PCR-proven SARS-CoV-2...

Another thought is that people on SSRIs seem to have low plasma serotonin, see here for example: Use of selective serotonin reuptake inhibitors is associated with very low plasma-free serotonin concentrations in humans, 2019 From that 2019 study, people on SSRIs had dramatically lower serotonin...

From the supplementary charts. Figure S2B is the age of the cohorts. Recovered is in grey, and is, on average, a lot younger than the acute Covid and PASC cohorts. Figure S2C is the sex mix of the cohorts. PASC is on the right, there appears to be a much higher percentage of females in the...

My first question is - are the levels of serotonin really different in LC? It would be a bit surprising, as, if it were that simple, you would think we would know that already. So, my set point is skepticism. This is Figure 1J of serotonin levels, sorry it came out blurry. The columns are...

Here's a paragraph from the paper worth quoting: It strikes me as very much in the vein of 'it's those people over there that have this problem, not those of us who are educated and smart'. Sometimes it is suggested that poor people and people in developing countries don't get functional...

'Eye-opening' as in 'utterly incredible that people in this century believe this sort of Freudian codswallop'? It's fine to quote sentences or paragraphs to make a point. It's the same standard of thinking as 'she didn't want to hear what the world was telling her, so she got ear-ache' and...

In that diagram in post #2 - Etiology

What's going on? Another review finding that commonly held beliefs that prop up the "functional disease" construct don't hold up. And this one has Jon Stone as an author. So, it seems that neither depression nor anxiety (and neither presence nor severity of these problems) have any impact on...

Indeed. Even when the patient goes on to have florid symptoms of some physical disease that without question would have caused the initial symptoms, even when the patient dies of that physical disease, we have seen published case studies where the initial diagnosis of a 'functional disease', a...

Several posts on CFS and ME as distinct diseases have been moved to Diagnosis of ME and the use of the labels ME and CFS.

Contributors/supervisors listed as: + Mullins, B + Jenner, S + Anderson, C + Williams, F + Holdaway, C + Hankinson, L Presumably some of those were involved just on one of the three projects, not necessarily the 'psychological intervention for CFS review'. University of Oxford. It's quite...

Looks like lower cortisol levels only in mild and moderate males - and there were only 8 of them in total. I haven't read the paper yet, but I think, as I've said before many times, cortisol levels aren't telling us anything about disease pathology. Yeah, I'd go with the 'everything too noisy'...

Maybe bigger than gigantic? Gigantic map of fly brain is a first for a complex animal

Bioimpedance spectroscopy characterization of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) peripheral blood mononuclear cells Sara Martínez Rodríguez1, Alberto Olmo Fernández 2,3 *, Daniel Martín Fernández 3,4, Isabel Martín-Garrido 1,5...

Ah, of course. Thanks for the pictures. I understand why the investigators used the historical group, so as to avoid confounding with asymptomatic infections, but it does increase the possibility of some confounding with different experimental techniques. It will be great to see some...

Interesting , thank you SNT. They say 2/3 of the post-Covid people had the platelet clumps at day 40. What percentage of the healthy controls had platelet clumps at day 40? They also say that the likelihood of having the platelet clumps at day 40 was aligned with acute disease severity (but not...