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Gene expression profiles See Fig. 9: Male and female cohorts have distinct differential gene expression profiles in the muscle. The title claims that male and female cohorts are different when it comes to gene expression in muscle. I could believe that. But look at the PCA charts: Figure a...

Childhood Trauma and Sexual and Physical Abuse It's mentioned in the Methodology that the participants completed the Childhood Trauma Questionnaire Short Form and the Sexual and Physical Abuse Questionnaire. In the paper, this is all I can find about this, in the discussion: By only reporting...

I think the answer might lie in the age distributions. With about 45% of the healthy controls in the 50 to 60 year age range, you have a lot of people feeling older, perhaps having some issues with menopause too, and so tending to not feel quite as sharp as they did when they were in their 30s...

I've wondered the same. I think it's highly likely that Walitt and his friend Shorter are well connected with the BPS people who delayed progress on the new Cochrane exercise therapy review with their complaint. I'm sure there is plenty of communication and that drafts of the paper were shared...

It's interesting to go back to the Phoenix Rising threads. Here's some excerpts from one of my posts in March 2017, complaining about including Walitt and a number of other overtly psychosomatic believers in the trial staff. It looks like, to start with, the NIH were suggesting that Walitt was...

That's excellent, Trish. Real life, it's complicated. Thank you for using so much of your scarce energy to provide that feedback. I'd add an additional problem to Trish's summary: the scope for bias, from the patient and from the clinician Retrospective evaluations are highly subject to...

The IOM criteria are not straightforward to apply. Do I have PEM half of the time? No, because I manage my activity levels to mostly avoid that. I don't have "unusual fatigue after exertion" most of the time because I often try not to exert in a way that produces that outcome. (I don't...

More on that and looking at that S8B figure again - For a start, just looking at where the data points are on the x axis - the percentage of hard-task choices a participant made in an investigation of decision-making - there's very little difference between the ME/CFS group and the healthy...

Far be it for me to speculate on whether Paul Garner actually did fully recover. But I do note that, soon after his much publicised recovery, he resigned his role as Professor at a school of medicine, and retired.

It would be fantastic if some of our members applied to be AfME trustees. When is the application deadline?

Here's Supplementary Figure S8B. It's the one that supposedly relates to the effort preference for the CPET study. I don't know what the 'Proportion hard task choices' are. @Snow Leopard? Edit - I understand now - the choice of hard tasks has nothing to do with the CPET - it was a separate...

This makes me a bit angry. From the Supplementary Information Page 8 Clearly the ME/CFS participants were reporting a lot more disordered sleep symptoms, but the conclusions in the paper and the supplementary information suggests that the sleep lab found nothing. But, "sleep fragmentation...

First off, it's important to note the small sample size. For these basic investigations, they've mostly all been done before, and generally haven't shown anything. I guess they had to repeat them, but, with that small sample size, they aren't telling us anything new, or in a newly convincing...

Good: Nothing, not even CBT and GET, are regarded as effective disease modifying treatments. So, that's helpful. Bad: Matching They claim that there were no significant differences. They only had to match 17 people. And yet the percentage of males is quite different (48% in the healthy...

I guess there's Paul Garner too, who got Long Covid and has since signed a range of BPS papers.

Terrific stuff. Carol Monaghan is a star. Also well done to @NelliePledge for her work getting more organisations, like the APPG, on board with the Cochrane exercise therapy review campaign.

Thanks @Andy, fixed

Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients, Bertinat et al (2022) It's past my bedtime, too late to think about how Bertinat's findings relate to the 2004 paper. Someone might want to have a think about it.

Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with CFS 2003 Khan, Spence et al A thread on a similar paper by the same team - has some commentary from @Ravn.

I felt the need to double check the year in the title - this paper could just as easily have been written now, in 2024, not 2004.