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There's been some discussion about the single CPET, and some persuasive arguments for just using the one CPET. The thing is, as Todd Davenport says, the measures reduce from CPET to CPET in ME/CFS (and presumably also with other pre-test activity). If it's true that CPET measures that are...

Some posts have been moved to a new thread: Grip test results and brain imaging in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al To help navigation between the threads, links have been added to the first post in each thread. Please use the contact moderators button on any...

I think the health professional might be doing some wishful thinking. Someone could cough on you and give you a pretty substantial dose in five minutes.

It was a marvellous idea Rob, and you executed it brilliantly. Tom, your contribution to the ME/CFS has been, and continues to be, enormous, with your analysis and writing, your creation of an international network and your ongoing efforts to inform and motivate people.... If only all people...

Quite possibly. Where does it say that the reward for the easy task was always $1?

Angus's ideas are discussed here: Thesis: A neuroinflammatory paradigm can explain Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome and Post-COVID-19 Fatigue Syndrome

Except that there is strength in numbers, especially numbers who share a common sense of outrage. I can't imagine lots of people with GWI and Long Covid will be thrilled to hear that they have a phobia of life, movement, social engagement, exercise ...

I'm still not understanding how the experiment worked. If you look at the source data, a single trial e.g. Trial 1, had a specified fixed probability of a reward, and a specified fixed reward e.g. 0.88 and $4.50. And you could choose either a hard task or an easy task. There does not seem to...

I think a well-matched control group is useful in studies like this. Even if there is some information about OI issues in the general population as determined by tilt tests, there might be specifics that make things different in this study. Perhaps there is something about the disease group...

I think that excerpt on treatments is pretty bad. It does not make it clear that the trials to date do not show that GET is effective - and that NICE found that GET didn't work. It doesn't work! If something doesn't work, then you don't have to write a whole lot of equivocal stuff about the...

@Paddler, thank you for being here and telling us about your experience. And thank you for volunteering for the study. If I had been eligible to participate in this study, I would have tried to, even though I strongly criticised the inclusion of Walitt, and the Shorter talk. Just the same as...

https://www.healthrising.org/blog/2024/02/27/nath-chronic-fatigue-syndrome-nih/ Cort is doing a 3-part series on the study. This was interesting, I don't know if it is true that the second visit was only a couple of days: Cort has got quite a lot of things wrong in his write-up. That's not...

Thanks Evergreen If I sort the data by trial number, I see that, for each trial, the reward amount is the same, and the probability of the reward is the same. That's true regardless of whether the participant chooses the easy or hard option. I find it incredible if that was really the case -...

There is that Jason et al study of OI in Me/CFS just out The Head-Up Tilt Table Test as a Measure of Autonomic Functioning among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2024, Jason During the tilt test, 32.5% of the participants demonstrated POTS or OH. (study didn't...

10 minute tilt, POTS defined by heart rate increase >=30 bpm OH decrease <=20mmHg in systolic blood pressure or <=10 mmh/g of diastolic blood pressure within 3 mins of tilt Yeah, no controls...

The team must surely be amassing so much useful information about how to run a GWAS for ME/CFS (and a GWAS in general, and an ME/CFS registry, and all sorts of associated things). Even if not every question could be perfect, they will now know so much. And that will be partly down to the...

Very good points. Check out this paper, from 2013, my first hit from google: Diagnosing Postural Tachycardia Syndrome: Comparison of Tilt Test versus Standing Hemodynamics which concludes and notes Basically they are saying that the tilt test is more extreme, so you either have a fairly...

Thanks SNT. The interest in this paper is because the NIH Walitt et al paper reported the slope of the Dimitrov Index.

:) Yeah, if we take those words at face value, then that would make the HV's stupid and the PI-ME/CFS participants smart. Because, if you are faced with the choice of two tasks with equal rewards and equal probabilities of receiving the reward, then why would you not choose the easy task? But...

On the Dimitrov index, a number of the interesting papers are paywalled. But this one isn't: Muscle conduction velocity, surface electromyography variable and echo intensity during concentric and eccentric failure. concentric is contracting exercise; eccentric is stretching; isometric is like...