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  1. Obermann

    Response: Sharpe, Goldsmith and Chalder fail to restore confidence in the PACE trial findings

    Well argued response, Tom and Carolyn. :) I am sure that even Professor Sharpe will see the light! ;)
  2. Obermann

    Do graded activity therapies cause harm in chronic fatigue syndrome? (Kindlon, 2017)

    Solid and scientifically sound criticism of the reporting of harm in GET trials. As always, it is a pleasure to read your papers, Tom! :thumbup:
  3. Obermann

    Sweden: Acceptance & Commitment Therapy for ME/CFS – A feasibility study, 2019, Jonsjö et al

    Even though this is a feasibility study, the lack of control group, blinding, and objective outcomes is a major problem. It is clearly stated in the text that the intention was to evaluate adaptation, acceptability, safety, and preliminary efficacy. The design means that there is no way to...
  4. Obermann

    Twitter activity of Professor Blanchflower

    It reminds me of the comment by Nasim Marie Jafry on the dialogue between James David Chapman and Professor Danny Blanchflower. The Mutual Admiration Society in session ...
  5. Obermann

    Twitter activity of Professor Blanchflower

    I appreciate that figures such as unemployment can be defined in different ways, and that both Blanchflower’s and Guido Fawkes’s statements must be put in a political context. However, I think that we are way off topic now. I didn’t intend to make any political statement, neither left-wing nor...
  6. Obermann

    Twitter activity of Professor Blanchflower

    I would like to add that I agree that no one should attack Professor Blanchflower—or anyone else—on a personal level. One should definitely not try to portray him as incompetent in his field. I think that few of us have the competence to evaluate his merits as an economist—at least I do not...
  7. Obermann

    Twitter activity of Professor Blanchflower

    I am well aware that the blog post on Blanchflower’s predictions only reflects the opinion of the blogger, who may have an agenda of his own. Your point that we shouldn’t pass judgement on Blanchflower as an economist is taken, although my post was intended to be satirical rather than judgemental.
  8. Obermann

    Twitter activity of Professor Blanchflower

    Professor Blanchflower seems to make categorical and ill-conceived statements not only about ME/CFS, but also in his own area of expertise. If he is 100% wrong when he makes predictions in economics, I wonder how wrong his rants about ME/CFS are? :sneaky:
  9. Obermann

    Twitter activity of Professor Blanchflower

    I think that many of us have noticed the presence of Professor Danny Blanchflower on Twitter. He is an old friend of Professor Peter D White and has been aggressively defending the PACE trial. He uses abusive language—for example calls patients with ME/CFS “whiners”—and quickly blocks people who...
  10. Obermann

    Who said: Labeling patients with ME or CFS keeps them sick

    Thanks for the info. We have a biopsychosocial fanatic in Sweden, Dr Jörgen Malmquist, who repeatedly has claimed that the name of the illness should be changed from "chronic fatigue syndrome" to "fatigue syndrome", because the term "chronic" suggests that nothing will improve and thus will make...
  11. Obermann

    Who said: 80% of ME is post-infectious

    The relative number of cases that are triggered by an infection is typically in the interval 70–80%. Wessely states 72%, Evengård 80% (2003), and the NIH workshop 78%. There is a study by Palacios among nurses in the US where only 19% of the cases are triggered by infection. I don’t know why...
  12. Obermann

    A Swedish reporter is interested in reporting on the PACE Trial

    I agree, she seems legitimate. She has written about ME/CFS on the web page of the National Swedish Television. She says that it is a neurological illness, that the name chronic fatigue syndrome is misleading, and that the National Institutes of Health has upgraded the priority for ME/CFS...
  13. Obermann

    Were historic 'ME' outbreaks really ME?

    I think it is quite clear that the meaning of the term ME has shifted, and that it originally referred to an acute illness with a strong propensity to trigger the chronic syndrome that we now refer to as ME/CFS. There were many outbreaks of the acute polio-like illness. Although the agent(s)...
  14. Obermann

    Re-framing GET as pacing, or vice-versa

    I think that the terminology has always been ambiguous. “Graded” does not necessarily mean that the activity level should increase. A paper by Wallman et al in 2004 uses the word graded exercise in the title. However, when the exercise program is described in the text it says: “Subjects were...
  15. Obermann

    Cochrane review and the PACE trial

    I think we need to stress over and over again that the main criticism of the PACE study concerns the basic design flaws. They used subjective outcomes in a study that was not blinded, and they conflated chronic fatigue with ME/CFS. Yes, they also manipulated the results to boost the subjective...
  16. Obermann

    Rethinking the treatment of chronic fatigue syndrome—A reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT

    Great article! I am looking forward to the published version. :thumbup: Many thanks to the authors for this important paper! :hug:
  17. Obermann

    What are the 'missing' research papers based on existing data that we wish scientists would write about ME/CFS?

    I would like an update of the 2006 paper by Anthony Komaroff, "Top Ten Discoveries about the Biology of CFS". It was embedded in another article by Komaroff, "What Causes CFS", which was published in a special issue of The CFIDS Chronicle.
  18. Obermann

    2011 Alastair M Santhouse funny BMJ letter re PACE, etc: Acknowledge good intentions of researchers in CFS/ME.

    The title says that we should acknowledge good intentions of researchers, but the text implicitly asks us to accept conclusions that are contradicted by the data. Nonresponsive statements of biased parties such as The Lancet or The SMC are not an acceptable rebuttal of criticism. Incorrect...
  19. Obermann

    Tutorial: The Practical Application of Longitudinal Structural Equation Mediation Models in Clinical Trials (2017) Chalder et al

    Suggested alternative title: Tutorial: The Practical Guide How to Create a (Bio)psychosocial Pseudomodel for an Illness of Arbitrary Etiology
  20. Obermann

    Tutorial: The Practical Application of Longitudinal Structural Equation Mediation Models in Clinical Trials (2017) Chalder et al

    For crying out loud. Is the PACE team going to teach us about Structural Equation Models? Embarrassing. Their analysis uses subjective outcomes and excludes all biomedical factors. Talk about begging the biopsychosocial question. Any expert in the field could explain for Goldsmith et al. that...
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