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You are perfectly right of course @Trish. None of us laypeople is going to work out the solution for a problem in such a complex biological system, no illusions there. I suspect one of the reasons we entertain ourselves with much happy speculating regardless is that we suffer from a couple of...

This potential ME-trigger-to-tryptophan route is mighty confusing. On the one hand stressors and infections can upregulate IDO and TDO, potentially causing tryptophan to decrease. On the other hand certain infections (unfortunately the usual ME suspects were not tested in this study) are...

I've only read the abstract which I interpret - in/correctly? - as not referring to tryptophan synthesis but only to tryptophan metabolism, i.e. the conversion of – presumably dietary - tryptophan into other metabolites such as kynurenic acid. Does the article itself say anything more? It's too...

@mariovitali What about TDO, do you know? That's in the liver I understand but the question is could it be downregulated by any of the typical ME triggers like EBV? Or could it be generally downregulated if there were the sort of liver problems you talk about? Edit: typo - corrected TPO to TDO

You ask a lot of good questions in your blog @Jenny TipsforME, so good I'd like to highlight just a few here. This had entered my mind, too. The way the hypothesis was presented I could understand how it could explain switching into – or out of – ME mode, a sudden on/off switch. Sure, this...

You're welcome @paolo. I do enjoy your blog and often find it helpful when trying to get my head around a complex ME issue. Though in this particular case your mechanical analogy didn't work for me, too abstract for my way of thinking maybe? But I'm sure it's just perfect for somebody else; we...

As I understand it the actual trap hypothesis is more concerned with IDO1 inhibition than TDO (plus of course the IDO2 fault) but if what you say about TDO is correct, @Stewart, that could certainly be one way to explain the initiation of the trap, which is exactly what my question was. For this...

I have a possibly dumb question about the trap After watching Phair's presentation plus reading about it on a blog (https://paolomaccallini.com/2018/10/08/is-it-a-trap/) I think I understand the concept of the metabolic trap. What I don't understand is how it gets started. I get that there has...

Will the relevant authorities/people see the recent re-analysis of the ME Cochrane review? Can somebody make sure they do? http://journals.sagepub.com/doi/full/10.1177/2055102918805187 Discussed here...

Always nice to see the establishment of another ME research center, especially one featuring new (new to me anyway) names. The more the merrier! @mariovitali will find this one interesting: Jon Jacobs (my bolding) ;) Edit: corrected tag

Yes, funding organisations are typically conservative but like to see themselves as progressive and cutting edge. That's why I think Moreau would likely be one of the few ticking both boxes. No idea, sorry. But somebody at the Stanford symposium said they thought possibly all the approaches...

How about linking in with work done on microRNA by Prof Alain Moreau who recently presented his findings at Stanford and CMRC2018? Health Canada is likely to feel safer looking at options involving Canadian researchers already established and internationally respected in the field of ME...

Yes, I've always been a bit confused by Ros' statements, too. On the one hand she always mentions physiological underpinnings (more or less well researched) and how severe the illness can be. On the other hand she often expresses herself in a way that leaves you with an impression of all...

This still happening except that when I added my 1 star - for lack of a zero star rating! - average rating of 1 star based on 1 rating of 4 stars and 21 ratings of 1 star. So it looks like people are trying to down vote this but it just keeps going back to the single 4 star rating. Could it be...

This thread reminded me of one of Cort's blogs discussing a connection between inflammation and the placebo effect. Note that the study this is based on is specific to depression (and that I haven't read the study and have zero idea of its quality): The Promise and Limitations of...

A couple of paragraphs jumped out at me in Cort's blog: Let's hope Jarred does get that money. Finding out what's happening in our brains after exertion - and coming at it from two angles, with Maureen Hanson doing the PET replication study - would be extremely interesting. Does anybody here...

Article doesn't say much more than how nice it'll be for MUS patients on the island of Fyn to finally have their own Center to go to where they'll be understood. All very nice and caring but there's no indication whatsoever that anyone at the new center might take the biomedical side of things...

Not about ME but parallels are not hard to find. The article is a highly entertaining account of assorted “medical opinion wars” throughout the last 200 years. Less entertaining and more disconcerting: many of our current debates – the diet wars, (anti-)vaccination, even BPS versus biomedical –...

Yes! I'm with you on that one @Barry. Not only is it fascinating to follow somebody else's out-of-the-box train of thought but it's in fact necessary to stop one's own thinking from getting stuck in a rut. Also agree with the numerous skeptics here: a somewhat vague and general hypothesis by...

No food allergies. A few minor Fodmap type intolerances but these don't seem to cause any more or less tinnitus than any other foods. It's more as if the act of digesting food, no matter what, triggers the tinnitus. Maybe something to do with a change in blood flow? Pure speculation, I really...