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Multimodal MRI reveals consistent basal ganglia and limbic system alterations in COVID-19 survivors The long-term impact of COVID-19 on the brain is multifaceted, encompassing structural and functional disruptions. A cohesive theory of the underlying mechanisms of the Post-COVID Syndrome (PCS)...

Relationship between body mass index, gray matter volume and peripheral inflammation in patients with post-COVID condition BACKGROUND Obesity, a condition associated with low-grade peripheral inflammation, is an independent risk factor for severe COVID-19 and has been linked to structural...

Done.

Well that's interesting. The content of the letter passed my immediate AI filter. They have written an editorial for the BMJ. https://www.bmj.com/content/390/bmj.r1268.short Department of Statistics and Data Science, Cornell University, Ithaca, NY, USA School of Mathematics, University of...

Sars-Cov-2 spike protein and plasma from COVID-19 patients induce extracellular traps by myeloid-derived suppressor cells INTRODUCTION Polymorphonuclear-myeloid-derived suppressor cells (PMN-MDSC) are elevated in COVID-19 patients, playing a crucial role in suppressing the SARS-CoV-2 specific...

Letter to the editor — “Too small to succeed?” Rethinking efficacy claims in a solriamfetol trial for ME/CFS Zhihao Lei Web | DOI | PDF | Journal of Psychopharmacology | Paywall

They discussed potential implications —

And then you get Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Test Results With Persistent Physical Symptoms Among French Adults During the COVID-19 Pandemic (2022) —

Hi 22MrMan thank you for offering your perspective. I'm also sure if I had met Paul socially prior to my experience with Covid I would also have liked him. He has visited some unusual parts of the world and had many interesting experiences. I'm sure he's got some fantastic landscape and...

Asymptomatic infection in a proof-of-concept longitudinal study on SARS-CoV-2 vaccine recipients Individuals with asymptomatic SARS-CoV-2 infection can unknowingly transmit the virus, yet identifying such infections in vaccinated populations remains challenging. We conducted a longitudinal...

Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19 In susceptible patients, COVID-19 causes life-threatening disease driven by immune-mediated inflammatory lung injury. We have previously shown that multiple common host genetic variants are...

That's assuming that in the brain metabolic by-products are waste and that all are needed to be cleared rapidly. Lactate in particular might be a signalling molecule that the brain needs and a universal fuel. See Glymphatic clearance controls state-dependent changes in brain lactate...

(CA10 was pinged by DecodeME and has been previously identified in chronic pain, so speculatively there may be a link to circadian control of CSF production and glymphatic transit. I don't know if this isoform is known to be relevant in the choroid plexus though. Edit: just re looking at our...

Glymphatic clearance controls state-dependent changes in brain lactate concentration Brain lactate concentration is higher during wakefulness than in sleep. However, it is unknown why arousal is linked to an increase in brain lactate and why lactate declines within minutes of sleep. Here, we...

Association of foveal avascular zone FAZ enlargement with SARS-CoV-2 infection and long COVID-19 BACKGROUND As COVID-19 was found to affect small vessels of multiple organ systems, the purpose of the study is to describe the macular vessel density (VD) and the area of the foveal avascular zone...

Summary quotes from intro and discussion —

Despite looking at small numbers of hospitalised patients going on to LC vs recovered controls, this could be of interest. p53, mitochondria, EVs and platelets feature. Apart from the mitochondrial data, the increased RUNX2 finding replicates that of Upregulation of olfactory receptors and...