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Structural brain abnormalities and neuropsychiatric symptoms in post-COVID condition OBJECTIVES We aimed to cross-sectionally and longitudinally compare brain morphometry and neuropsychiatric symptoms, and evaluate their relationship, in participants with Post-Coronavirus Disease Condition...

So CBT leads to redefinition of recovery away from actual recovery to Recovery™.

Recovery from chronic fatigue syndrome: a reflexive thematic analysis of experiences of people before, during and after treatment INTRODUCTION Chronic fatigue syndrome (CFS) is a chronic illness marked by severe, medically unexplained fatigue. Cognitive behavioural therapy (CBT) moderately...

Excellent. And thank you in advance to the patients that are able to volunteer.

That link went somewhere random for me. Hopefully this one works. Two epigenetic markers of the fibromyalgia syndrome: A matched case-control study (2025)

I think we should have threads on S4ME for all these studies. Cloudflare has an outage at the moment so I can't get to Wiley. I'll try again in the morning.

Video in 2 parts posted on Bsky (5 mins in total). Dr Jason Goldman, President of the American College of Physicians responds definitively in the Q&A to this anti-science BS.

Measured in muscle, following significant exertion?

This paper shows elevated muscle lactate that is much slower to clear, following exertion sufficient to deplete phosphocreatine stores. Previous mentions here, here, here, here and here. It would likely be of benefit to repeat this study with rigorous inclusion criteria, rather than Fukuda...

Thanks @Evergreen for some reason I hadn't tagged that paper as muscle so missed it when looking at my papers list for the above comment. I don't think we have a thread for that 2012 paper, but I think we should take a closer look. Thread at Loss of capacity to recover from acidosis on repeat...

Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case–control study BACKGROUND Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of...

Psychosomatic medicine — "Elevating the flaw for over a century".

Now open-access.

I think this was paywalled originally but I had recorded it to be available in PubMed Central by 1st Dec. The journal now has it open-access directly.

Over to @jnmaciuch and others for expert assessment / evaluation of methods. But a couple of initial thoughts after reading this in the context of findings related to synaptic genes, AMPA receptors etc. 1. What's our muscle lactate doing? Following CPET. Do we know? Ie if there is muscle...

Results cont'd —

Results (cont'd) — See our tag for lactylation.

Results (cont'd) — I didn't see it defined but I think otMDV means "over-trained mitochondrial derived vesicles" (and con for control.) (FWIW, pathways I recall we see repeatedly highlighted in ME transcriptomics studies though that may be pretty generic.)

From results — (Then investigated with mice doing moderate or vigorous exercise, assessed via novel object recognition test and the Morris water maze.)