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It's reduced filling pressures (and here they're measuring right atrial area in 2D echocardiography as substitute for RA volume). [27] is Systrom's Unexplained Exertional Dyspnea Caused by Low Ventricular Filling Pressures: Results from Clinical Invasive Cardiopulmonary Exercise Testing (2016...

Usual unblinded, subjective outcomes crap. CBT and GET. Modern Neuroscience™.

Assessing a multicomponent intervention to improve quality of life in individuals with Long COVID COVIDL/MIQoL: study protocol for a randomized controlled trial Morera, Mireia; Arévalo, Antonio; Garriga, Cristina; Corral-Magaña, Marta; García-Arqué, Mari Carmen; Gragea-Nocete, Marta; Pérez Díaz...

I think this is a very readable paper, sensibly describing great basic clinical science (+maths, physics, chemistry) and a very good study overall. It's one that I have added to the "What studies should we do?" thread.

Replicating and expanding Blood volume deficit in postural orthostatic tachycardia syndrome assessed by semiautomated carbon monoxide rebreathing (2024, Clinical Autonomic Research) to include ME/CFS patients, not just pw"POTS". Ideally: correlating with OI and other symptoms severity, FUNCAP...

Case in point from Reddit just now: Having fun at the ER

"multiple ED nurses told us they’d never even heard of ME/CFS" Their affected colleagues just mysteriously left after developing "anxiety" because ED is such a stressful environment.

Somewhat analogous to Edward Shorter, who is a historian (BA, MA, PhD) not an MD/psychiatrist but is a professor in the Dept of Psychiatry at Toronto.

No he has no training in anaesthesia itself. From the 2008 profile linked above — None of that directly translates to practical knowledge of anaesthesia: particularly as it relates to perioperative or critical care. It crosses into chronic pain management, but looking at the ORCID record his...

@dave30th you might want to clarify (perhaps in any future piece) that Busse is not a "professor of anaesthesiology". He's a professor in the Dept of Anesthesia. Anaesthesiology is a medical speciality - ie you need an MD/equivalent and then 5-8 yrs specialty training to be an...

Nature News: How the brain spies on the gut: with help from newfound immune cells

The three metabotypes identified in A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome (2021, JCI Insight) See In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling (2021, Proteomes)

Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights August Hoel; Fredrik Hoel; Sissel Elisabeth Furesund Dyrstad; Henrique Chapola; Ingrid Gurvin Rekeland; Kristin Risa; Kine Alme; Kari Sorland; Karl Albert Brokstad; Hans-Peter Marti; Olav Mella; Oystein...

Some quotes, out of order — [12] is Transfer of IgG from Long COVID patients induces symptomology in mice (2024, Preprint: BioRxiv)

Preload insufficiency as common denominator of exertional dyspnoea in distinct post-COVID phenotypes G Oruqaj; K Lo; K Krüger; P Bauer; L Laufer; K Milger; C Tabeling; I Pink; Z Rako; N Kremer; S Yildiz; J Behr; M Hecker; M Kaya; S Kuhnert; HH Krämer-Best; U Matt; S Herold; S Oberwinkler; J...

23 rapid responses to date. According to the indexes in the URLs all but 10, 13, 14, 17 have been published.

Many options are going to equate to "central sensitisation". Maybe consider de-emphasising the over/hyper-responsiveness aspect and keep it more general, as in "neuro-immune dysregulation". (Edit: fix tautology)

Haven't read the paper but here's the Wikipedia page on the subfornical organ. One of the interface regions (like the area postrema) without the normal blood-brain barrier. Of particular relevance would be these Wiki passages —

That's quite a change from the usual "you won't possibly improve if you involve yourself with patient support groups".