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Increased Risk of Post-Acute Sequalae of COVID-19 in Patients With Immune-Mediated Inflammatory Diseases Evangelin Shaloom Vitus; Christian Nikolai Sørensen; Anastasia Karachalia Sandri; Rahma Elmahdi; Tine Jess BACKGROUND AND AIMS Dysregulation of the immune system and chronic inflammation...

BPS flags flying strongly here though: Interestingly, some these supposed abnormal illness beliefs seem to be absence of symptoms — Many recovered with no treatment —

I've chosen to put this FND paper in the main LC forum rather than the purely psychosomatic one. It's open access, useful in that it describes their use of positive signs. While it includes some of the inevitable problematic framing, it does report on spontaneous recovery. And as these authors...

Contemporary positive signs of functional limb weakness in post-acute sequelae of SARS-CoV-2: an exploratory analysis of their utility in diagnosis and follow-up Takashi Osada; Hiroaki Kimura; Terunori Sano; Masaki Takao BACKGROUND Sequelae of the acute phase of coronavirus disease-19, termed...

Large-scale psychometric assessment and validation of the Modified COVID-19 Yorkshire Rehabilitation Scale C19-YRSm patient-reported outcome measure for Long COVID or Post-COVID syndrome Mike Horton; Adam Smith; Stephen Halpin; Ruairidh Milne; Darren Winch; Clare Rayner; Roman Rocha Lawrence...

Exercise Intolerance and Response to Training in Patients With Postacute Sequelae of SARS-CoV2 Long COVID: A Scientific Statement From the American Heart Association William K. Cornwell; Benjamin D. Levine; Diane Baptiste; Nicole Bhave; Sarika Desai; Elizabeth Dineen; Matthew Durstenfeld; Justin...

Now we need to see bigger numbers, using fresh rather than frozen samples. And unlike the ubiquitous BPS "promising", this looks like it actually has potential ;)

See also Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts (2023) —

Similar in cardiac muscle cells. SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations (2025). Just five patients (with myocarditis) —

So should be available in ~24 hours. Noted by Joan Crawford in this thread.

See also Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children MIS-C (2024)

Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children MIS-C Bellos, Evangelos and 97 others Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic...

This thread has comments describing the experiences of athletes developing ME/CFS, including significant worsening after pushing through.

Discussed at this point during the Action For ME / Genetics Centre of Excellence Webinar - 06 June 2025

Published as — Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals Sardell; Das; Taylor; Stubberfield; Malinowski; Strivens; Gardner We present a novel method for routinely identifying...

Editorial on Effects of Physical Exercise on Functional Physical Performance in Individuals With Long COVID: A Systematic Review (2025)

Jon Stone discriminated as — So I guess incongruence is "this doesn't make sense given what we (think we) know". Inconsistent sounds ostensibly more straightforward in that behaviour is shown to be different under the voluntary vs automatic scenarios. However I think that's similar to...

They're a bit out of date on FND too. Structural alterations in functional neurological disorder and related conditions: a software and hardware problem? (2019) Reduced microstructural white matter integrity is associated with the severity of physical symptoms in functional neurological...