Search results

Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18 Fan, Fanfan; Wang, Jun; Liu, Kun; Zhang, Shiyue; Gao, Jian; Li, Xiongfei; Ma, Jiaqiang; Zhao, Yue; Li, Teng; Su, Han; Yang, Xinfeng; Han, Han; Huang, Qingyuan; Zhang, Yiliang; Pan, Yunjian; Ye, Ting...

Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis (2025) Guo, Weijie; Huang, Sihao; Shao, Xiangli; Wu, Yuting; Ma, Yuan; Lu, Shuya; Ren, Hanlin; Zhou, Xuening; Yang, Zhenglin; Lyu, Mingkuan; Liu, Yiwei; Gordon, Vernita; Brodbelt, Jennifer S.; Pan, Tao...

Wuhan strain of SARS-CoV-2 triggers activation of immune evasion machinery similar to the one operated by cancer cells Abooali, Maryam ; Yasinska, Inna M. ; Thapa, Gauri ; Lei, Xi ; da Costa, Kelly A. S. ; Schlichtner, Stephanie ; Berger, Steffen M. ; Fasler-Kan, Elizaveta ; Temperton, Nigel J...

It's entirely arbitrary. It's a biological disorder that induces brain dysfunction that manifests in specific ways. Unlike the tremors and motor disturbances (and cognitive dysfunction) of Parkinson's, unlike the sensory and motor disturbances of demyelinating process, that may vary spatially...

Protective role of anti-SARS-CoV-2 antibody responses against vital organ related long COVID symptoms Yukari Magawa, Jhosiene; Jacintho, Lucas Cauê; Alves Ferreira, Marcelo; Ramos Oliveira, Jamille; Rahal Guaragna Machado, Rafael; Kuramoto Takara, Andreia; Moreno Lima de Oliveira, Renata...

The standout in my mind is the 5 min poster presentation on preliminary findings in muscle capillary basement membrane thickening. I suspect this is what Grigor is referring to here. This could tie up with the acquired mitochondrial disorder Systrom is describing above. Leading to fuel...

You might like this recent overview of their decade long investigations with invasive cardiopulmonary exercise tests (18 min).

Requested by @hotblack

Requested by @hotblack

Common Variants within MECP2 Confer Risk of Systemic Lupus Erythematosus Amr H. Sawalha; Ryan Webb; Shizhong Han; Jennifer A. Kelly; Kenneth M. Kaufman; Robert P. Kimberly; Marta E. Alarcón-Riquelme; Judith A. James; Timothy J. Vyse; Gary S. Gilkeson; Chan-Bum Choi; R. Hal Scofield; Sang-Cheol...

Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus Ryan Webb; Jonathan D. Wren; Matlock Jeffries; Jennifer A. Kelly; Kenneth M. Kaufman; Yuhong Tang; Mark...

Endothelial TERT drives microvascular phenotype associated with coronary artery disease Erin C. Birch; Yoshinori Nishijima; Shelby N. Hader; Andreas M. Beyer Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed...

On that brief description, I'm going to take a punt that that was Gorham's disease (aka "vanishing bone disease") and that it might be successfully treated with sirolimus (rapamycin). Whatever the actual diagnosis, fingers crossed for the best outcome for your friend's little girl. The problem...

Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing Manganotti, Paolo; Iscra, Katerina; Furlanis, Giovanni; Michelutti, Marco; Miladinović, Aleksandar; Menichelli, Alina; Cerio, Ivan; Accardo, Agostino; Dore, Franca; Ajčević, Miloš Cognitive...

COVID-19 Patients Have Peripheral Microvascular Dysfunction and Tissue Hypoxia in Spite of Successful Treatment of Lung Failure: A Proof of Concept Study Knut Kvernebo; L. Liv Kristin Wikslund; Kamila Drezek; Andrea Jaramillo; Luigino Capone; Maged Helmy; Yunong Zhao; Aaron Aguirre; David...

"suggest that we have an acquired mitochondrial problem. It's likely not a genetic form." "The baseline studies suggest we have a decrease in what's called mitochondrial biomass […] the number of mitochondrial in the skeletal muscle." "And this is very, very different from the genetic form of...

Edit: cross-posted with Wigglethemouse in the OMF thread.

MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway Xinqi Mao; Jianzhang Wang; Shaojie Ding; Xinyue Guo; Xinxin Xu; Ping Xu; Xinmei Zhang The studies on how mast cells mediate endometriosis pain are still...