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Evidence for a heritable predisposition to Chronic Fatigue Syndrome Albright, Frederick; Light, Kathleen; Light, Alan; Bateman, Lucinda; Cannon-Albright, Lisa A Chronic Fatigue Syndrome (CFS) came to attention in the 1980s, but initial investigations did not find organic causes. Now decades...

Conclusion —

Health economic outcomes and national economic impacts associated with Long COVID in England and Scotland Kwon, Joseph; Mensah, Joseph; Milne, Ruairidh; Rayner, Clare; Lawrence, Román Rocha; De Kock, Johannes; Sivan, Manoj; Petrou, Stavros Background Two million people in the UK suffer from...

The Critical Role of the Bile Acid Receptor TGR5 in Energy Homeostasis: Insights into Physiology and Therapeutic Potential Zangerolamo, Lucas; Carvalho, Marina; Barbosa, Helena C. L. Over the past decades, bile acids have been recognized as important signaling molecules with significant roles...

Pitt Is Launching a Chiropractic Program—What Happens When Pseudoscience Gets an Academic Seal of Approval? "Evidence-based chiropractor" replies in defence, quoting the proposed curriculum, implying it's fully in line with evidence-based medicine — I think @rvallee's head may explode.

Very well articulated.

Note that Young appears to have been suspended from BlueSky.

I'll see if I can access it later. It may be that their point relates to diagnostic overlap as "fibromyalgia with PEM" could simply be ME/CFS where the patient or doctor promoted the pain symptoms which ended up influencing the classification. It sounds like they are asking for the same sorts...

Recognizing the role of fibromyalgia in post-exertional malaise Alessandro Giollo; Mariangela Salvato; Andrea Doria The recent opinion by Charlton et al. published in Trends in Endocrinology & Metabolism [1] provides a thought-provoking discussion of the overlap between long coronavirus disease...

I think that tweet relates to Skeletal muscle adaptations and post-exertional malaise in long COVID (2024) not this preprint.

Now published in PNAS — Oxidative stress is a shared characteristic of ME/CFS and Long COVID Shankar, Vishnu; Wilhelmy, Julie; Curtis, Ellis J.; Michael, Basil; Cervantes, Layla; Mallajosyula, Vamsee; Davis, Ronald W.; Snyder, Michael; Younis, Shady; Robinson, William H.; Shankar, Sadasivan...

Now published in PNAS — Patient-reported treatment outcomes in ME/CFS and long COVID Eckey, Martha; Li, Peng; Morrison, Braxton; Bergquist, Jonas; Davis, Ronald W.; Xiao, Wenzhong ABSTRACT Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are persistent multisystem...

Validity of the test for attentional performance in neurological post-COVID condition Seibert, Susan; Eckert, Irina; Widmann, Catherine N.; Ebrahimi, Taraneh; Bösl, Fabian; Franke, Christiana; Prüss, Harald; Schultze, Joachim L.; Petzold, Gabor C.; Shirvani, Omid Neurological post-COVID...

And their reported average time to reach definition of improvement (20 weeks) sounds close to the 6 month peak with Rituximab you described in the saline thread.

Rituximab binds to SMPDL3B in muscle. See A novel estrogen receptor 1: sphingomyelin phosphodiesterase acid-like 3B pathway mediates rituximab response in myositis patients (2022) EDIT: I see that is actually referenced in this thread's paper as [28] —

Comprehensive molecular characterization of post-COVID condition: Immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers Seco-Gonzalez; Antelo-Riveiro; Bravo; Domínguez-Santalla; Rodríguez-Ruiz; Piñeiro; Garcia-Fandino BACKGROUND Post-COVID condition...

Annexin–Membrane Interactions Across Eukaryotic Domains of Life—A Comparative Approach Warmus, Dawid; Balmer, Erina Alexandra; Faso, Carmen This review explores the interaction of annexins with membranes across a variety of eukaryotic domains of life, highlighting this protein family’s role in...

See also historical Increased neutrophil apoptosis in chronic fatigue syndrome (2004)

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