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Now published (early access) — Abnormal T-Cell activation and cytotoxic T-Cell frequency discriminate symptom severity in myalgic encephalomyelitis/chronic fatigue syndrome BACKGROUND Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating but poorly-understood disease...

Marc Veldhoen wrote a Substack article on this paper. Concluding — https://marcveldhoen.substack.com/p/persistent-attenuation-of-lymphocyte

Another example of GET associated with worsening of symptoms to severe.

Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination Messenger RNA (mRNA) vaccines against SARS-CoV-2 are highly effective and were instrumental in curbing the COVID-19 pandemic. However, rare cases of noninfective myocarditis...

Nature: Huge genetic study reveals hidden links between psychiatric conditions Progress.

Mapping the genetic landscape across 14 psychiatric disorders Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar...

Even if this and SGB were shown to be effective in a blinded trial, it's completely impractical beyond a few patients.

For orthostatic intolerance separate to neurodegenerative diseases, there seems to be a blind spot in relation to autonomic nervous system innervation of brain vasculature (and circulating chemical messenger control). As well as interactions with the trigeminovascular system. See various...

Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies Nociplastic pain has recently been introduced as a third entity for identifying patients suffering from chronic pain that arises from altered nociception...

Occupational determinants of Long COVID in the population-based COVICAT cohort OBJECTIVES Occupational factors affect SARS-CoV-2 infection risk, but the occupational factors associated with Long COVID (LC) are unknown. We aimed to address this issue using individual data in a population-based...

Thank you - noted. I think that's 0700 my time so I should be able to watch live (or later if the morning is being unkind). I see there's this video from six months ago also.

GRIN2A gets a mention in dispatches with LC too. SARS-CoV-2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin (2025) Exploring the mechanisms of long COVID: Insights from computational analysis of...

Referencing Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology (2021, Clinical Neurophysiology) A "full battery" does not...

Autonomic function testing and symptom severity in patients with suspected mast cell activation disorders We assessed both objective and subjective measures of autonomic severity in patients with formally classified mast cell activation disorder (MCAD), hereditary alpha tryptasemia (HaT), and...

Enrolled 119 (62% male) Non-completers 47 (40%) Exercise per week following COVID-19 infection (self-reported) No exercise 53 (43%) < 150 min/ week 38 (31%) ≥ 150 min/week 10 (8%) Unclear 20 (17%) [15] Effectiveness and tolerance of exercise interventions for long COVID: a systematic review...

Ahhhh... "Novel", "Multi-disciplinary", "Incorporates Exercise" :banghead:

Safety and Physical Outcomes of a Novel Australian Multidisciplinary Long COVID Clinic That Incorporates Exercise: A Prospective Observational Study BACKGROUND Exercise therapy remains somewhat controversial in those with Long COVID (symptoms lasting > 3 months), due to concerns for safety and...

Fukuda. I don't think there's any point reading further.

Microstructural White Matter Impairments in Chronic Fatigue Syndrome: Evidence of Segmental Injury in the Cingulum Bundle BACKGROUND Chronic fatigue syndrome (CFS) is a neurological disorder characterized by persistent fatigue. Previous studies have shown structural and functional brain...