Search results

Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge Severe symptoms in the absence of measurable body pathology are a frequent hallmark of post-COVID syndrome. From a Bayesian Brain perspective, such symptoms can be explained by...

Screening for postural orthostatic tachycardia syndrome using 24-hour electrocardiogram recording in patients with long coronavirus disease BACKGROUND Cardiovascular autonomic dysfunction is a major complication in a large proportion of patients with long coronavirus disease (LC). As one of...

Listed as one of the top 20 research articles for 2024 in American Family Physician Am Fam Physician: Top 20 Research Studies of 2024 for Primary Care Physicians

Archived at https://archive.is/wKiWu

From the introduction —

He lasted three months. Science Based Medicine: COVID-19 contrarian Dr. Vinay Prasad meets real world responsibility BioSpace.com: Prasad Out at CBER Following Sarepta Rollercoaster and Conservative Criticism

Just to add my n=1 to the PEM vs muscle weakness question — When I was severe I could barely lift my arms or move my legs. I could very slowly drag myself to the toilet 2x/day. I recall that when things were really bad I could only lie still all day, and with an irritating itch or painful neck...

I think we missed this back in May, but Cort has posted an article at HR — Turning the Pain up in Fibromyalgia (and ME/CFS?): The Antibody-Mast Cell Connection

The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells Fibromyalgia syndrome (FMS) is characterized by elevated levels of immunoglobulin G (IgG), altered bowel habits, and increased pain sensitivity, suggesting immune dysregulation, but the exact mechanism...

Blood-Brain barrier disruption in long COVID and cognitive correlates: A cross-sectional MRI study Disruption of the blood–brain barrier (BBB) may contribute to neuropsychiatric symptoms observed in Long COVID (LC). Using a non-contrast magnetic resonance imaging (MRI) technique, we...

Peripheral immune progression to long COVID is associated with mitochondrial gene transcription: A meta-analysis SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has led to millions of cases of Long COVID worldwide. Long COVID is a phenomenon characterized by persistent and...

Symptomatic Trends and Time to Recovery for Long COVID Patients Infected During the Omicron Phase BACKGROUND Since the pathophysiology of long COVID is not yet fully understood, there are no specific methods for its treatment; however, its individual symptoms can currently be treated. Long...

Published as — A Signal for Voice and Speech Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Grach, Stephanie L.; Seltzer, Jaime; Orbelo, Diana M. BACKGROUND/OBJECTIVES Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may report abnormalities in...

Second review article on this, this week. See also The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction (2025, International Journal of Molecular Sciences)

See also Lactylation and viral infections: A novel link between metabolic reprogramming and immune regulation (2025, PLOS Pathogens)

The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction Ma, Fei; Yu, Wei Glycolysis and oxidative phosphorylation are the main pathways of cellular energy production. Glucose is metabolized via glycolysis to generate pyruvate, which, under anaerobic conditions, is...

Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome (2009) found PFKFB3 to be decreased in muscle cells.

Sex differences in inflammation and markers of gut integrity in long COVID Endothelial damage represents an essential pathogenic mechanism of respiratory and multiorgan dysfunction as seen in the post-acute phase of COVID-19. Biological differences between male and female sex, inflammation...

Pre-COVID health-related quality of life predicts symptoms and outcomes for patients with long COVID Lapin, Brittany; Baker, Samantha; Thompson, Nicolas; Li, Yadi; Milinovich, Alex; Lago, William; Katzan, Irene BACKGROUND Post-acute sequelae SARS-CoV-2 (PASC) is a prevalent condition with...

Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort BACKGROUND Social determinants of health (SDoH) contribute to disparities in SARS-CoV-2 infection, but their associations with long COVID are unknown. OBJECTIVE To determine associations between SDoH at the...