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Noting in reference to the DecodeME thread — My question would be could Covid infections impair/reduce regulatory autoantibodies against BNIP3 that are present in HCs, so that loss-of-function of FBXL4 and now loss of anti-BNIP3 AAbs leads to a rise in BNIP3 above threshold. More mitophagy...

Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection Pediatric SARS-CoV-2 infection results in clinical presentations ranging from asymptomatic/mild infection to severe pulmonary COVID-19, to Multisystem Inflammatory Syndrome in Children...

(Insulin-like growth factor 1 and sex hormone binding globulin)

https://www.coresinai.org/manual The manual is 6.5 MB and about 160 pages.

Circulating FGF-21 as a Disease-Modifying Factor Associated with Distinct Symptoms and Cognitive Profiles in Myalgic Encephalomyelitis and Fibromyalgia Myalgic encephalomyelitis (ME) and fibromyalgia (FM) are overlapping syndromes characterized by persistent fatigue, cognitive difficulties...

[47] is — A Brief Molecular History of Vγ9Vδ2 TCR-Mediated Phosphoantigen Sensing Web | PDF | Immunological Reviews | Open Access See also Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells (2020, Science)

Done.

Haha, I might just have to do that this morning!

But with white matter microstructural imaging, maybe the cat's out of the bag. It will inevitably be used more and more until it's routine, eg in Parkinson's: A worldwide study of white matter microstructural alterations in people living with Parkinson’s disease (2024, Nature npj Parkinson's...

WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome (2023) —

Stress-induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy Lee; Amy S Since their discoveries in the 1960s as a family of proteins produced by cells in response to stress, molecular chaperones are increasingly recognized as major...

Design and validation of an energy level diary for fatigue management in patients with post-COVID syndrome BACKGROUND Post-COVID syndrome (PCS) is a frequent condition with an incidence of 7.8–10.6 per 100 unvaccinated and 3.5–5.3 events per 100 vaccinated persons. Cognitive and motor fatigue...

Pain among US adults before, during, and after the COVID-19 pandemic: a study using the 2019 to 2023 National Health Interview Survey Zajacova, Anna; Grol-Prokopczyk, Hanna; Nahin, Richard L The unprecedented disruption of the COVID-19 pandemic raises crucial questions about its impact on...

Things will improve when neuroimaging advances. Currently, even in established MS, MRI may show lesions as well as normal appearing white matter (NAWM). Pathologically, NAWM is not normal but looks normal on routine imaging, which is a good way to end up with the concept of "co-morbid FND"...

A couple of recent papers on achalasia. A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia (2023, Nature Communications) Focus on Achalasia in the Omics Era (2024, International Journal of Molecular...

A few time zones. Thu, 7 Aug — mostly middle of the night, so something to wake up to if any sleep is forthcoming ;) Auckland 06:00 Sydney 04:00 Melbourne 04:00 Perth 02:00 Tokyo 03:00 Beijing 02:00 Wed, 6 Aug New Delhi 23:30 Berlin 20:00 London 19:00 New York 14:00 Los Angeles 11:00 Vancouver...

Ignoring improvement and just comparing totals for any worsening category: much worse, moderately worse, slightly worse — GET (162 + 57 + 27) / 299 = 82%, 54% being "much worse" (ME = 263, LC = 36) Pacing (10 + 9 + 9) / 803 = 2.2%, 1.2% being "much worse" (ME = 684, LC = 119)

See published study Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera (2025)