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Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice INTRODUCTION Allergic reactions to food are mediated by cross-linking of preformed food-specific immunoglobulin E (IgE) antibodies bound to tissue mast cells upon allergen exposure. However, some...

Following a question — @Jonathan Edwards

Without posting screenshots I'll quote from Emma Wall's (Francis Crick Institute / UCLH / StimulateICP) talk: "An Innate Inflammatory Signature Is Consistently Enriched in the Plasma of Adults Living with Long COVID Across all Clinical Symptom Groups" Regarding plasma proteomics —...

From the Conference Policies —

Mitochondrial function is impaired in long COVID patients BACKGROUND The Long COVID syndrome is a major global health problem, affecting approximately 10–20% of individuals infected with SARS-CoV-2 virus with many remaining symptomatic beyond one year. Fatigue, reduced exercise tolerance and...

Experiences of pacing to reduce symptoms among adults living with Long COVID in Canada, Ireland, the United Kingdom and the United States BACKGROUND Long COVID is a multisystem condition that negatively impacts daily function. Pacing is a self-management strategy to mitigate symptoms. Our aim...

Automatic detection of persistent physiological changes after COVID infection via wearable devices with potential for long COVID management Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to post-acute sequelae of SARS-CoV-2 infection (PASC), or Long COVID, a...

(Two whole years! Crikey.)

The impact of acute COVID-19 symptoms on insomnia: A longitudinal study among medical students OBJECTIVE The COVID-19 pandemic has profoundly disrupted global mental health. Medical students, already vulnerable to high stress, experience heightened psychological distress. This study aimed to...

Michelle Scoullar (paediatrician) from the Burnet Institute runs the paediatric side of a private long covid clinic in Australia. She's seen just over 60 patients, the youngest 5 ("definitely long Covid"). Relatively equal sex distribution which she suspects is likely to reflect...

That's measuring PRDX6 in extracellular vesicles, which might mean it's exocytosed and less available in ME cells following exercise.

Peroxiredoxin 6 mediates the protective function of curcumin pretreatment in acute lung injury induced by serum from patients undergoing one-lung ventilation in vitro (2022, BMC Pulmonary Medicine) Peroxiredoxin 6 in Stress Orchestration and Disease Interplay (2025, Antioxidants)

Reddit discussion —

(AI transcript above hasn't got Sarah's name quite right: "Booby" -> "Boothby") Sue's story at 28:50 is incredible. Healthcare professional, marathon runner, surfer, cyclist, ran her own business, mother etc. Was told to do more and more. Worsened and was told it was behavioural, that she was...

In limitations —

Their defining reference is Updated%20NICE%20guidance%20on%20chronic%20fatigue%20syndrome%20(2020,%20BMJ)']Updated NICE guidance on chronic fatigue syndrome[/URL] (2020, Turner-Stokes and Wade) !! 70% male. Duration of illness 3.4 ± 1.3 months. The results are presented as "Vitamin D Yes/No"...

We still have the X chromosome data to come and there are some receptors there: IL-2R and some other IL-nRs. The X chromosome has other potentially rich pickings eg: neuroligins, various zinc finger proteins, some ubiquitins, TLR-7, synaptophysin, pyruvate dehydrogenase, some NADH dehydrogenase...

Commenting in the main DecodeME thread: BNIP3 has links to HIF-1⍺, iron metabolism and the proteasome. This paper suggests a bi-directional upregulation between BNIP3 and HIF-1⍺ (in a melanoma model). BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis...

[27] posted on thread A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease (2023)

A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood. Here, via...