Re: MAIT T cells being found in the meninges in Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function (2022)
Yes the claim is that they're tissue-resident, as part of the barrier function of meninges. From the...
Intro on how they define fatigability (fatiguability?) vs fatigue, ie objective vs subjective —
The term "Fatigability" does not appear in Walitt et al (2024). But note that objective fatigability here is defined is reduction in output despite willed effort. If "fatigue" is the subjective...
MicroRNAs in long COVID: roles, diagnostic biomarker potential and detection
Long COVID or Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), marked by persistent symptoms lasting weeks to months after acute SARS-CoV-2 infection, affects multiple organ systems including the respiratory...
Incidence of Long COVID Following Reinfection with COVID-19
M Daniel Brannock; Emily Hadley; Alexander Preiss; Megan L Fitzgerald; Nita Jain; Emily Taylor; Andrew Wylam; Yun J Yoo; Elaine Hill; Richard A Moffitt; N3C Consortium; RECOVER Consortium
BACKGROUND
COVID-19 reinfections have emerged...
I hope mods agree it's OK for me to offer the following.
@Alinda assuming that trace is from when you're asleep, that looks like a pattern of cyclic HR variation of the sort that can be seen in sleep-disordered breathing, including obstructive sleep apnoea. Your smartwatch may be right to be...
Long COVID in children and young people: then and now
PURPOSE OF REVIEW
On 11 March 2020, the WHO characterized COVID-19 as a pandemic. A clinical case definition for post-COVID-19 condition in children and adolescents by expert consensus was agreed by the WHO in 2023. It is now 5 years since...
It was more an overview, history and call to arms talk. He showed QoL and employment data for their 1000 adult cohort (terrible as you'd expect). He emphasised not becoming siloed with our pet hypotheses and to keep options open and work together.
"During the last four or five years...
During Danny Altmann's plenary, discussing the major impact on children they're seeing as part of their larger study —
"And it's very tough to see and it was hard for us because we found it very hard to get the funding agreed from our funder. Because at the last moment they said the advice...
The organisers are being strict about not posting slides, graphs, tables etc so we'll have to wait for the actual publications for data and ascertainment details. But they were emphasising fatigue, postural symptoms, myalgia, poor sleep and brain fog, so that sounds broadly in the ball park...
Work Impairment and Financial Outcomes Among Adults With vs Without Long COVID
IMPORTANCE
While much of the focus on long COVID (LC; defined as developing new, persistent symptoms lasting 3 months or longer after SARS-CoV-2 infection) has been on health status and quality of life, the impact...
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