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Commentary in Nature: The brain’s map of the body is surprisingly stable — even after a limb is lost

Stable cortical body maps before and after arm amputation The adult brain’s capacity for cortical reorganization remains debated. Using longitudinal neuroimaging in three adults, followed before and up to 5 years after arm amputation, we compared cortical activity elicited by movement of the...

Not always. Currently chronic traumatic encephalopathy is only confirmed post-mortem. In vivo neuroimaging techniques are still at the "promising" stage.

From commentary Rare skeletal condition caused by enzyme’s failure to rescue a catalytic cycle —

A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia Living cells depend on an intricate network of chemical reactions catalysed by enzymes, which sometimes make mistakes that lead to their inactivation. Here we report a metabolite-based mechanism for preserving enzyme...

SLC45A4 is a pain gene encoding a neuronal polyamine transporter Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can...

Metformin on the Presence of COVID-19 Symptoms Over 6 Months: The ACTIV-6 Randomized Clinical Trial BACKGROUND The effect of metformin on preventing long-term COVID-19 symptoms among low-risk adults has not been studied. The objective of this study was to Assess metformin compared with placebo...

Regarding a table of genes including neuroligin-1, Not necessarily exclusively though. Neuroligins are cell adhesion molecules that may be involved in immune cells also (both CNS and peripheral). They also relate to endothelial and vascular smooth muscle cells. There may be links to...

Posted in Reddit r/science by a professor of medicine.

In Multi-omic insights from a multi-ancestry genome-wide meta-analysis of ankylosing spondylitis reveal novel pathways of disease susceptibility (2025) — rs4848370 (nearby ACOXL) OR = 0.92, p 8x10-12

Posting due to previous discussions relating to Ank Spond and the potential for broadly similar mechanistic explanations that might be seen in ME. Eg

Summary quotes —

Interferon-Linked Lipid and Bile Acid Imbalance Uncovered in Ankylosing Spondylitis in a Sibling-Controlled Multi-Omics Study Ankylosing spondylitis (AS) displays wide inter-patient variability that is not accounted for by HLA-B27 alone, suggesting that additional immune and metabolic...

Grant recipient of NZ govt Health Research Council 260K award https://www.hrc.govt.nz/resources/research-repository/shining-light-functional-neurological-disorder-aotearoa-new-zealand Year: 2025 Duration: 36 months Approved budget: $260,000.00 Researchers: Mr Benjamin Scrivener, Professor...