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Nearly two years later I can answer myself: it did not!

Posting in relation to Zhang et al Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis (2025) — And from DecodeME —

See also recent review on N-degron N-degron pathways (2024, PNAS)

Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability Kim, Haeun; Tian, Ya-Min; Ratcliffe, Peter J; Keeley, Thomas P Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid, O2-dependent proteolysis via the Cys/Arg-branch of the...

The role of complement in long COVID pathogenesis Rafael Bayarri-Olmos; William Bain; Akiko Iwasaki Long COVID is a debilitating condition that can develop after a SARS-CoV-2 infection and is characterized by a wide range of chronic symptoms, including weakness, neurocognitive impairment...

Thanks Chris and team, I thought this paper was really useful. I may be biased from my personal subjective experiences and a few objective observations, but I think cerebral blood flow is a very important part of the pathology to pin down. To me it seems the obvious answer to the question...

@Shiqiru I'm sorry to read of your wife's lupus diagnosis. I noticed a paper this month from Liverpool that may be of interest. Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence (2025, Rheumatology) Also, regarding...

Paper from Dec 2024. PITX2 deficiency leads to atrial mitochondrial dysfunction AIMS Reduced left atrial PITX2 is associated with atrial cardiomyopathy and atrial fibrillation (AF). PITX2 is restricted to left atrial cardiomyocytes (aCMs) in the adult heart. The links between PITX2...

No question! I assumed it was being used to help with translation to/from English.

Mitochondrial activity tunes nociceptor resilience to excitotoxicity Lin Yuan; Navdeep S Chandel; David Julius The capsaicin receptor, TRPV1, mediates the detection of noxious chemical and thermal stimuli by nociceptors, primary sensory neurons of the pain pathway. Overactivation of TRPV1 leads...

Thank you for the post and additional detail. Reading the preprint, I understood that this may be relevant in two scenarios. The first is to try and determine people at risk for ARDS/SIRS (adult respiratory distress syndrome / systemic inflammatory response syndrome) in the acute setting...

The Conversation: Long COVID is more than fatigue. Our new study suggests its impact is similar to a stroke or Parkinson’s Sounds like it's being underplayed. No mention of the quality-of-life-reduction multiplier that is healthcare, and of course: rehab.

Impacts of long COVID on disability, function and quality of life for adults living in Australia BACKGROUND To describe the impact of long COVID on disability, function and quality of life among adults living in Australia. METHOD People aged >18years with a history of COVID-19 infection...

I'll wait til it's peer-reviewed. Meanwhile — pwME: "please support me with pain relief, nutrition and social supports" doctors: "nope" pwME: "..." also doctors:

The normal rule here is that the "spare" X chromosome in females is silenced by XIST to compensate for dosage. In males, apart from normal spermatogenesis, this can occur in cancer cells Somatic XIST activation and features of X chromosome inactivation in male human cancers (2022, Cell Systems)...

Distinguishing features of Long COVID identified through immune profiling (2023) showed elevated APRIL. They didn't highlight BAFF but it is in the supplementary raw data so presumably was not significantly different. (They also put a lot of emphasis on a low cortisol finding). FWIW 934 -...

v4 preprint on MedRxiv at https://www.medrxiv.org/content/10.1101/2025.02.13.25322223v4.full.pdf

Interferons in health and disease Daniel Boehmer; Ivan Zanoni Interferons (IFNs) are signaling proteins that play fundamental roles during health and disease. Although types I, II, and III IFNs are structurally and functionally different, all IFNs signal via an intricate network of Janus...