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The paper discusses the possible explanations —

Now published — Altered amyloid plasma profile in patients with disabling headaches after SARS-CoV-2 infection and vaccination BACKGROUND AND OBJECTIVES Persistent headache has emerged as a symptom following acute COVID-19 and, to a lesser extent, after SARS-CoV-2 vaccination. However, the...

Points I emphasised in behind-the-scenes response discussions.

Some other papers of potential interest relating to CD38 — CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels (2020) Web | PDF | Nature Metabolism | Paywall Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+...

Small cohorts 20 PASC vs 10 CONV, with unbalanced sex: 90% female in PASC and 50% female in CONV. Nevertheless quite a lot of discussion on MAIT T cells, aberrant class switching (IgG1 and IgG3 dominant in PASC, IgG2 and IgG4 dominant in CONV). My arrow highlights IGHV3-30-3, which was the...

Regulation of m7G methylation in long COVID: Expression profiles and early predictive value of key genes Bai, Wenmei; Li, Fengsen Long COVID (LC) poses ongoing public health challenges due to its persistent symptoms following severe acute respiratory syndrome coronavirus 2 infection. Early...

What’s the most ridiculous explanation a doctor has given you Another good list of some of the BS medicine inflicts on people. Shout out to —

In fact they've taken the entire website down.

Merged ------------ It looks like this was instigated at the May Charité conference, but has been announced on social media today. Possibly we've noted this previously. https://declaration.mecfs-research.org/en/declaration Recognizing: That millions of individuals worldwide are suffering...

My counselling psychologist ended our therapeutic relationship as I "do not challenge myself" in regards to CFS Notable for the number of (appalled) psychotherapists with ME/CFS replying in the comments. I doubt they'd be pleased reading Jake Hollis.

No mention of PEM. OK - good to see some objective measures. Anyway, looking at their 2024 portfolio - I don't know if it is exhaustive - in the "under development" section I also noted Pitolisant, which is an H3 inverse agonist acting as a CNS stimulant, FDA/EMA approved for narcolepsy and...

Noting this reply that encapsulates medicine's "thinking" —

Here's my quick-summary of passages I highlighted —

Intrigued to read that they think encephalitis lethargica is a somatic symptom disorder. Wikipedia — The German neurologist Felix Stern [de], who examined hundreds of encephalitis lethargica patients during the 1920s, noted that their encephalitis lethargica typically evolved over time: The...

I appreciate you can't read the papers, but I'll post links that others following the thread may be interested in. We have threads for — Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts (2025) Evaluation of...

Seasonal Coronavirus-Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID Long COVID (LC) is a post-acute infection syndrome affecting 5%–10% of individuals infected by SARS-CoV-2. Here, we aimed to study SARS-CoV-2 humoral immunity, immunological...

Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID: Self-reported Data From the LISTEN Study BACKGROUND Postural orthostatic tachycardia syndrome (POTS) has emerged as a significant cardiovascular phenotype among individuals experiencing postacute COVID-19 syndrome...

Interesting point on no clinically obvious major effect on brain function post colectomy. I don't think we've got studies on this to be sure and there may be up to decades latency so we might not pick it up. It's probably hard given that younger adults (eg IBD/UC) would be exposed to all sorts...

Wow. I had to double check that this was in fact published in 2025. Beyond the evidence base? Undoubtedly. The art of medicine? Please, go draw some pictures of old-world hospitals or something. This here is incompetent nonsense. Why always maintain optimism for recovery if the prognosis is...