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That's probably worth its own thread in psychosomatic news, as it was confidently promoted one day and debunked the following. I'll make a post. Edit: thread here

Now published as — A multi-omics recovery factor predicts long COVID in the IMPACC study BACKGROUND Following SARS-CoV-2 infection, ~10-35% of COVID-19 patients experience long COVID (LC), in which debilitating symptoms persist for at least three months. Elucidating biologic underpinnings of...

That seems a bit anaemic from the BPS people. "just maybe you might recover" "not with that attitude"

CSF immune cell alterations in women with neuropsychiatric Long COVID BACKGROUND Women are disproportionately affected by neuropsychiatric symptoms following recovery from acute COVID-19. However, whether there are central nervous system-specific changes in gene expression in women with...

From the discussion — LP Lamina propria MMC Mucosal mast cell

The paper is paywalled so I hadn't posted it back in August but I have made a thread now. Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens (2025, Science)

Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens INTRODUCTION Food allergies are a growing medical problem in the industrialized world. In the most extreme cases, allergic reactions manifest as anaphylaxis, a life-threatening state of...

Long Covid in Rwanda — Prevalence and characterization of post-acute sequelae of SARS-CoV-2 infection PASC in Rwanda (2025)

Prevalence and characterization of post-acute sequelae of SARS-CoV-2 infection PASC in Rwanda Rwamwejo; Niyonkuru; Rukundo; Remera; Rwagasore; Sztandera; Ruranga; Krebs BACKGROUND Reliable, population-level estimates of post-acute sequelae of SARS-CoV-2 infection (PASC) remain scarce for...

The paper's comments on amyloid microclots —

My notes of the main ideas presented — Fibrinogen is made by the liver and is soluble. With thrombin it forms initially small fibrin monomers (variably soluble to insoluble) which then aggregate to form a larger scaffold, which with platelets forms the typical clot. Apart from the timing to...

Maybe the fact sheet will be updated once DecodeME is peer-reviewed and published, but it could be argued to reference the preprint now given its strength? Content not relevant to this thread post-split has been greyed Fascinating on mono/glandular fever being unknown. EBV-driven malignancy is...

(Copied post: content not relevant to this split thread has been greyed) Maybe the fact sheet will be updated once DecodeME is peer-reviewed and published, but it could be argued to reference the preprint now given its strength? Fascinating on mono/glandular fever being unknown. EBV-driven...

Posting in reference to discussion on these tracers and TSPO in the recent Stanford Symposium, starting here.

See also this paywalled abstract from 2024 — Development and comparison of two novel PET tracers for imaging pro-inflammatory receptor GPR84 in human cells and tissues INTRODUCTION Inflammation is an essential biological process in response to injury or infection; however, its failure to...

PET Imaging of Innate Immune Activation Using 11C Radiotracers Targeting GPR84 Chronic innate immune activation is a key hallmark of many neurological diseases and is known to result in the upregulation of GPR84 in myeloid cells (macrophages, microglia, and monocytes). As such, GPR84 can...

I'm assuming that's the region I've arrowed here. This is a mid-coronal slice which I've matched approximately to an MR atlas slice. I think the very bright red above and below will be uptake in gluteal and short adductor muscles respectively. The low uptake dark regions will be the femoral...

I suspect we'll be discussing these studies and their possible implications quite a bit. I think the observation on proximal musculature and particularly the reference to the coat hanger pain distribution is intriguing. We've only got selected images rather than the full dataset to review, but...

Carbonic anhydrase 1 is CA1. Noting that CA10 was a significant gene in DecodeME, although that may not be relevant as CA10 is acatalytic and likely has a completely different function, in specific tissues.