Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects
The physical tissue microenvironment regulates cell state and behaviour. How mechanical confinement rewires the subcellular localisation of organelles and affects cellular metabolism is largely...
That's a really useful article @ME/CFS Science Blog - thank you. Looking forward to the next in the series. I'll try and find some articles that tie identified genes to the new post-synaptic AMPA receptor findings (X looks like it marks the spot quite nicely).
I spotted one instance of...
Prevalence and Clinical Impact of Postural Orthostatic Tachycardia Syndrome in Highly Symptomatic Long COVID
BACKGROUND
The incidence of postural orthostatic tachycardia syndrome (POTS) in long COVID has been a growing concern since the first cases were reported in 2021. The aim of this study...
Erythrocytes as a Source of Exerkines
Exercise activates many metabolic and signaling pathways in skeletal muscle and other tissues and cells, causing numerous systemic beneficial metabolic effects. Traditionally recognized for their principal role in oxygen (O2) transport, erythrocytes have...
That's the corresponding author. It's a consortium involving researchers in UK, Ireland, The Netherlands, France and US. Patient numbers were relatively small though.
Exploring Alice in Wonderland syndrome in adults with persistent headache after COVID-19: a cross-sectional study in Latin America
BACKGROUND
Alice in Wonderland syndrome (AIWS) is a neuropsychiatric disorder characterized by sensory perception distortions, including altered body image...
Long COVID After Acquisition of the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2 During Pregnancy Compared With Outside of Pregnancy
OBJECTIVE
To evaluate whether the risk of long COVID among individuals infected with severe acute respiratory syndrome...
Coincidentally announced today is FDA approval for a phase 2 study on AMPAR modulation from a Welsh biotech.
Note that this is upregulating AMPAR function, impaired in depression. See https://en.wikipedia.org/wiki/AMPA_receptor_positive_allosteric_modulator
Now published as —
Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients
The persistence of vasculo-thrombotic complications has been put forward as a possible contributing factor in the Long COVID (LC)...
Polygenic and developmental profiles of autism differ by age at diagnosis
Although autism has historically been conceptualized as a condition that emerges in early childhood1,2, many autistic people are diagnosed later in life3,4,5. It is unknown whether earlier-and later-diagnosed autism have...
Lead author (along with Chalder and 40 others) of Post-Hospitalisation COVID-19 Rehabilitation PHOSP-R: A randomised controlled trial of exercise-based rehabilitation (2025)
This paper looks to be of importance, particularly given DecodeME’s identification of synapse-related genes.
Before delving into findings some framing through the paper is notable.
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