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I think someone with M.D. in front of their name is always wrong ;)

What Can We Learn Four Years On? A Multi-Centre Service Evaluation Exploring Symptoms, Functional Impact, Recovery and Care Pathways in Long Covid BACKGROUND Long Covid (LC) is associated with long-term health impacts that require ongoing support from healthcare services. We aimed to gain...

The related thread we have is Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression, 2019, Jin+ [two age groups]. Tag made for two age peaks to keep track.

Older paper (2014) predating S4ME, but relevant for review due to — See general discussion thread The two age peaks in onset of ME/CFS.

I've made a thread at Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012 (2014)

Merged thread ------------------- Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012 BACKGROUND The aim of the current study was to estimate sex-and age-specific incidence rates of chronic fatigue...

Audio link: https://www.rnz.co.nz/national/programmes/ninetonoon/audio/2019011538/otago-survey-finds-healthcare-failing-long-covid-patients

That paper's cohort are patients with myeloma, and they are characterised as extensively pre-treated. Could a reduced CD38 expression on plasma cells more generally be an environmental effect (eg a precursor requirement) before you can even get to the clonal expansion seen in myeloma? Ie is it...

Selected quotes from discussion —

Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation The cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-cyclic GMP-AMP (cGAMP)-stimulator of interferon genes (STING) pathway mediates antiviral innate...

Just because it was referenced on Bsky today here also is the thread from 10 months ago from Mark Ungrin PhD. This all sounds depressingly familiar @dave30th.

[8] is Severity, predictors and clinical correlates of Post-COVID syndrome PCS in Germany: A prospective, multi-centre, population-based cohort study (2022) It's invasive. Also not pleasant, if any of you like me have had this sort of thing done. Perhaps ethical approval couldn't include...

Growth Differentiation Factor-15 Is Considered a Predictive Biomarker of Long COVID in Non-hospitalized Patients (2024) Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights (2025) Heightened innate immunity may trigger chronic inflammation, fatigue...

SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes SARS-CoV-2 infection is associated with long-lasting neuropsychiatric and cognitive symptoms, collectively referred to as neuro-PASC. Emerging studies indicates that accelerate brain aging and...

Investigating apoptosis in peripheral blood mononuclear cells among the elderly in the post-COVID-19 era Abiri, Elaheh; Hemmatian, Najmeh BACKGROUND AND AIM The COVID-19 pandemic has left a lasting imprint on immune function, particularly in the elderly—a population already vulnerable to...