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That distinction actually incentivises the direction of research dollars where they should be going, because if something is in the good bet column, and not yet consensus, it needs money spending on it.

I'd also add that A4ME's role in the PACE scandal is an extremely important analogy that hadn't occurred to me and ME Action should take note. That kind of embroilment occurs from principles being mixed up.

Thank you again @Michiel Tack for this. I think that @Jonathan Edwards, @Trish and @strategist covered the appropriate issues wonderfully in reply also. These are powerful contributions. I think that it's possible that this wider conversation, including recent more specific threads, is caused...

The balance between the three types of energy impact does definitely vary for me, and presumably across people too. I am also pretty sure that, for me, cumulative adrenaline does come with a come down eventually. It's a function of too many things to even be sure something is, or isn't, a...

Any energy usage, whether physical, cognitive or emotional, is ME relevant. Let alone high level of any of these... (All regardless of this article thread)

I knew the other papers, but not Jason 1999. Usable CI ranges, which I needed. Thanks!

Apart from anything else, I also noticed for the first time that I have been using a wrong alternate spelling for Wessely....

Thanks again. I'm a relative newbie compared to you guys who are in the bricks. My knowledge, wrt what I need to know, ranges from 99% to 20%. Where I am missing information is an unknown unknown. So thank you for digressing, it is useful contextualisation.

Many thanks. Didn't realise they adopted some of Fakuda Yup, indeed, thanks! Just fixed it to match my own article link. Two Ws and brain hiccup.... Totally agree and all your additionally shared context is additionally invaluable. Totally agree also. Nucul's Fakuda based paper is...

Grateful if anyone can tag users who are major diagnostic-guideline / Wessely-school historians!

Many thanks for the gut response - invaluable. In terms of ME relevance, it was limited to my mind extrapolating potential and wanting to flag it for more expert imagination :)

Hello all, I am very familiar with the ICC, CC, CDC vs Oxford criteria discussion, prevalence differences, Oxford obfuscation, etc. but I have a very specific question about what the Wessely crew mean by "CF" vs "CFS". This is not merely academic and is of consequence for important ongoing...

Tagging @Jonathan Edwards V interested in what is speculatable as reasonable initial testable hypotheses wrt this and ME.

Yes, I have just DiY filleted myself. I now resemble a stress free meat pizza ;) @Wonko LOL re yr first paragraph. Multiquote not cooperating...

I should credit Richard Dawkins for posting it on FB - doesn't make my associating it with ME sensible yet

Exciting stuff, at least intrinsically. It's new to me - to the better informed? Spans a range of topics related to ME, at least tangentially. Seemed interesting to flag for those better equipped to comment. A question I would have is whether the post viral element of ME would be incompatible...

"Mediation of the acute stress response by the skeleton," Cell Metabolism (2019). DOI: 10.1016/j.cmet.2019.08.012 , https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30441-3 Mediation of the Acute Stress Response by the Skeleton Author links open overlay panelJulian...

Data would be the problem, presumably. Re the potential of not initially presupposing anything medically, we are now at the point where machine learning can predict the behaviour of the universe, dark matter and more in ways we didn't even expect...

Are there any time series studies that look at comorbidities statistically/ with machine learning as a pure data mining exercise to offer hypotheses for consideration to seed/direction real research (I saw the prevalence estimation machine learning paper)? I mean a paper without presupposing...

I have not read all these links properly. It's been merely a collation of a few others' collations