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Thank you, I appreciate it. This is very important thing to answer. The delay can be explained by the fact that expression of Irg1 doesn't really start until 4h post activation for example. Real meaningful itaconate levels happen even later. I would think that the delay would simply be the time...

@jnmaciuch I will answer point by point Are you saying that natural itaconate likely only inhibits interferon production via upregulating ROS generation, which in turn activates the Nrf2 pathway? No, ROS induced by itacoonate boost IFNb production. Due to it not being strong enough to induce...

The way CAD (I'm more used to IRG1) activation is described is not exhaustive. It is one of the pathways that can induce it. The reason I'm saying "Type I IFN" is that it is group of interferons alpha and beta that both signal through IFNAR receptor. Yes there is definitely a positive feedback...

To the connection to ME/CFS I need to do a bit more reading on that. But from brief look that I could do, I like the itaconate hypothesis a lot. It is fitting and can explain the symptoms. But it needs experimental verification. I can see a connection through it being a self sustaining...

@V.R.T. No I'm saying the exact opposite. Itaconate boosts Type I IFN production in activated macrophages as we showed both in vitro and in vivo. I'm saying that itaconate derivatives do the exact opposite. But you will not find the derivatives inside the cells or your body. That's the main...

@Mij Thank you for highliting our work. If you have questions feel free to ask.

Good, I was worried it's some form of autotranslation. I wouldn't like that. Thank you for the kind touch.

Thank you! Is it just me or is it really written in Slovak?

The same applies to the inhibition of cGAS/STING pathway. It is not itaconate, but derivatives that were shown to modify STING and inhibit it's activity. This is one thing artyomov lab has been heavily pushing, to abandon derivatives and study natural itaconate or at least stop using...

Hi I'm Tom, lead author of the itaconate Prdx5 story. I would suggest Caution with relation of itaconate and inhibition of type I interferon (IFNa and IFNb). Research of itaconate often heavily relies on the itaconate derivatives like dimethyl itaconate (DI) or 4-octyl itaconate (4OI)...