Search results for query: FURIN

Just copying their findings from the supplementary tables so the genes come up in forum searches. For the snps, I converted them to the genes they map to with dbSNP's API. Variants Transcription Proteins

...the upregulation of antisense ORF1ab RNA suggests ongoing viral replication. SARS-CoV-2-related host RNAs (ACE2/TMPRSS2 receptors, DPP4/FURIN proteases) and RNAs prototypical for memory B-cells and platelets4 were also upregulated." Also IgE RNA upregulated, which may be related to...

...enzyme (ACE)-2 and/or neuropilin (NRP)-1, for initial adhesion to cell surface; then utilizes two major host proteases, TMPRSS2 and/or furin, to gain cellular entry; and finally employs an endosomal enzyme, cathepsin L (CTSL) for fusogenic release of its viral genome. The virus-induced HMRD...

I've reformatted to add links to GeneCards. From supplementary materials, in order the 70 (FDR) DEGs are —

...RNA was remarkably low/absent. In addition, several SARSCOV2-realted host genes were also increased in LC (ACE2/TMPRSS2 receptors and DPP4/FURIN proteases). Other upregulated RNAs were specific for memory B cells (CD27/IGHE/BMP8A), and platelets (CD99/PBX1/PDZK1IP1). Platelet transcripts were...

Some quotes that may be relevant more widely than malignancy —

This is interesting. So potentially some methods of measuring TGF-B, maybe the methods that chop proteins up into little bits, might not accurately report the activity capacity of the protein?

From an earlier long piece, this time New York Magazine: The Lab Leak Hypothesis (Jan 2021) —

...silico mutagenesis analysis, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach, we provide genetic evidence for putative drug effects, highlighting...

...what the data on genes in ME/CFS was like. One of the databases they used was disgenet.org. disgenet.org. reports an association with the FURIN gene. Unfortunately the database contains garbage. Just look at this https://www.disgenet.org/browser/0/1/1/C0015674/ Amusingly, the FURIN gene is...

Here's something about Serpina 5 - I'm posting it at least partly because I like the title: Cell penetrating SERPINA5 (Protein C inhibitor, PCI): More questions than answers A 2016 paper, perhaps coincidentally by two people also based in Vienna. SERPINA5 binds glycosaminoglycans...

Well that’s interesting. One of the symptoms I had whilst covid infected was earache. It was a stabbing pain occurred just over a couple of days and then just stopped. This reoccurred a few times over the next 6 months as short bouts of the same stabbing pain that would come and go in less than...

Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction https://www.nature.com/articles/s43856-021-00044-w.pdf @Mij

This report talks about it I think https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 One virologist talks about cell infectivity but that it is unclear how this relates to transmission

It looks like the hypothesis that SARS-CoV-2 accidentally escaped from a lab in Wuhan is still on the cards... In the article the authors explain the flaws of the Andersen paper (which was posted earlier in this thread) as well as give a detailed description of their own hypothesis...

Neuropilin-1 is a host factor for SARS-CoV-2 infection James L. Daly, Boris Simonetti, Carlos Antón-Plágaro, Maia Kavanagh Williamson, Deborah K. Shoemark, Lorena Simón-Gracia, Katja Klein, Michael Bauer, Reka Hollandi, Urs F. Greber, Peter Horvath, Richard B. Sessions, Ari Helenius, Julian A...

Open access at https://www.frontiersin.org/articles/10.3389/fnins.2019.00301/full