Search results for query: NEGR1

These are the main candidate genes suggested by the data from the DecodeME study based on different methods: Tier 1 and 2 genes as defined by the DecodeME paper, significant genes using MAGMA test, and the nearest genes to the top 25 most significant loci. I posted the same information on the...

Here's an attempt to bring together all of the main candidate genes from different sources: Tier 1 genes, tier 2 genes, genes significant in MAGMA, and the gene (or two genes if it is not clear) closest to a locus for the top 25 loci. Sources: Tier 1 and 2 genes: Candidate genes document...

Is it possible people with depression are more prone to ME? Or that a percentage of depression cases are actually people with the prodromal form of ME, whether or not it ever turns into the real thing?

...correlation means that ME/CFS and depression show signals in the same genomic regions even if these did not reach significance. An example is NEGR1 which has been implicated in depression GWAS. If we look at this region in ME/CFS, then there is a signal close to this gene with a p-value...

...Chromosome 1 69.69 LRRC7 Educational attainment, bone density, BMI, adolescent idiopathic scoliosis, depression/anxiety Chromosome 1 73.12 NEGR1 Intelligence, insomnia, socioeconomic status, BMI, schizophrenia, ADHD, autism, depression Chromosome 1 73.12 LRRIQ3 Education attainment...

...what I got: ID p-value Odds ratio Frequency Closest genes 1:69696474:A:G 2.06e-7 1.09 0.18 LRRC7 1:73126414:C:CA 1.19e-7 1.07 0.49 NEGR1, LRRIQ3 1:91028158:C:T 1.89e-7 1.07 0.44 ZNF64, BARHL2 6:4336259:T:C 2.90e-7 0.92 0.19 (unclear) 11:16217844:C:G 1.08e-7 1.12 0.10 SOX6...

...stats on the GWAS Atlas website. I'm not sure if it has data from exactly the same study you linked, but it has several for depression. For example, there's a depression trait which looks like it has NEGR1 as significant. Clicking the link next to "File" gives a 625 MB file with these columns:

Coming back to OLMF4 and NEGR1, two genes which had significant SNPs close to them in a big depression GWAS: Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics DecodeME also has SNPs close to these genes that were...

...disorders under the bus. Otherwise, I'm excited for any connection between ME/CFS and depression that might arise, like the potential NEGR1 gene connection. Finding similarities doesn't suddenly change whether exercise would help. It's clear it doesn't. Instead it's like how long COVID got...

NEGR1 and DCC were the only two genes that were significant in both males and females (using different tests). NEGR1 and DCC also happen to be the genes closest to the 10th and 15th most significant loci in the DecodeME study (though below the genome-wide significance threshold at 1.19e-7 and...

Sex-stratified genome-wide association meta-analysis of major depressive disorder Jodi T. Thomas, Jackson G. Thorp, Floris Huider, Poppy Z. Grimes, Rujia Wang, Pierre Youssef, Jonathan R. I. Coleman, Enda M. Byrne, Mark Adams, BIONIC consortium, The GLAD Study, Sarah E. Medland, Ian B. Hickie...

...were significant as well. (It was at this point I decided to search PubMed for "depression neurons" just to explore, and I saw a paper about NEGR1, which reminded me that I saw this gene in the locus above, which led to the above post.) I next ran it on a dataset called "Brain and Organ...

Yes this is one of the top hits for depression, discussed in this big depression GWAS: Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions | Nature Neuroscience

The above was the 10th most significant locus in the main GWAS (though its p-value of 1.19e-7 didn't pass the genome-wide threshold). NEGR1 appears to be the closest gene. Lead variant: 1:73,126,414:C:CA There appears to be evidence linking NEGR1 to depression. Link to PubMed search for...