Yeah, where are the scatter plots? Which are kind of important info. If the plots supported the claims made by the PACE authors then they would...
They aren't biomarkers but ME/CFS is significantly disabling and so activity levels would be expected to be a reasonable proxy. The NHS classes...
Yes, good point. It had a statistically significant reduction in fatigue, but not physical function, and it wasn't maintained at follow-up. I'm...
Yes, they learned that a Dutch trial or trials had null results for it, so they decided it didn't accurately reflect "fatigue"--just as Knoop...
we had a rehab trial for severe patients, or at least homebound ones, called FINE. The PACE team kept touting it as their "sister trial"--but the...
That's how the researchers interpret it. But because of the reliance on subjective measures in unblinded trials, and the dismal performance on...
...Measuring activity for PwME was already thought of in the PACE trial, who used actimeters at the start of the trial and then went against their...
My goal is to help patients. What the PACE trial and the FITNET trial showed in long-term follow-up was that usual care eventually caught up...
...point is that the review claims that all of the issues with the PACE trial exaggerated the effect of GET. They did not. They created the...
Then where is the section in the main PACE trial paper published in 2011 with great publicity claiming efficacy for GET/CBT, showing that the...
Thread here: https://www.s4me.info/threads/brian-hughes-2018-psychology-in-crisis.5535/
Is there a detailed chapter by chapter summary of this somewhere? I’d very much like to read this but don’t have the energy to actually buy or...
...and anyone else interested, Professor Brian Hughes book Psychology in Crisis is and enlightening read. It even has a chapter on the PACE trial.
It's also important when making claims about efficacy to put them in context. Just saying there was as statistically significant improvement on...
NICE downgraded the evidence due to indirectness (not requiring PEM). It wasn't due to the quality of the evidence itself.
As we have already explained many times, patient organisations are rightly critical of badly designed trials. If someone proposed yet another...
Just a side note on this point, while it is often described this way - as something they planned to do and then "dropped" - the trial management...
And IIRC the committee that found that had a bunch of BPS people in it.
@dundrum Also some years ago after many analysis of PACE trial from experts and ME/CFS organisations and many complains there was an independent...
You keep repeating this claim as if that makes it true. I didn’t say it was fraudulent due to the bias. It’s fraudulent for many other reasons...
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