@dundrum, relating to the 6MWT in PACE, this is from the critique of PACE by Wilshire et al.: A number of other secondary outcome measures were...
Graded exercise therapy has not been shown to help. It has only been tested in open-label trials, and we have explained to you why subjective...
Please don't use the broken mitochondria again. It hurts and is very denegrating. Every ME/CFS patient has to find out for themselves what's wrong...
Yes, can't have something as petty as falsification getting in the way of the grand plan. The show must go on!
I forget but wasn't this the basis for the PACE trial steering committee abandoning altimetry as an endpoint in PACE be because it had been shown...
...treatments as they can't help severe people, that the PACE trial is "fraudulent", etc. (And yes, I'm aware that you said it is fraudulent. Not...
Indeed. They are lighter than a cotton t-shirt. Are they seriously suggesting that the weight of summer clothes is too much of a burden? It is a...
There is insufficient evidence in favour of the treatments (CBT and GET) and in favour of the underlying assumptions. There is, on the other...
...past that, with their symptom-titrated exercise trials. Action for ME was involved in the PACE trial, so they had every opportunity to improve it.
We've had plenty of trials of CBT. Patient organisations are not responsible for organising trials of low quality. If you've had numerous trials...
Actually, it looks like I posted the write article. The one I posted wasn't even a treatment trial, it just assessed stress management skills....
I have often wondered about these early studies. Fulcher and White 1997 is similarly promising - the exercise group had a 20 point increase in...
See this critique - the underlying study is on par with PACE (so completely useless)....
...compelling for doctors and for people considering funding the PACE trial. For sure, the subjective self-report measures combined with what I...
There it is again :jawdrop:! This time ‘many patients’ as your scientific, considered thought in the very comment you post straight after you...
...together as all having fear avoidance, which is what the PACE trial did. But still, it is a major issue for some patients. Clearly it's not...
Are you aware of the issues with the studies that PACE was based on?
...are many studies that have looked at this as well, and the PACE trial was based on it (you can look at the evidence they reference in their...
...April 2025 Part 2 of 2 Research ME/CFS research Life The PACE Trial’s GET Manual for Therapists Exposes the Fixed Incremental Nature of...
Why aren't they all suffering from PTSD, sleep, disturbance, migraines, chronic fatigue, depression, anxiety, chronic pain, tension headaches, or...
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