The abstract says this: Could that mean that the null hypothesis was that there is a difference? @Kronos And welcome to the forum!
These seem like very high p values to be getting from 18 people. I looked at the paper @InitialConditions posted and they did something similar...
Low-Dose Naltrexone restored TRPM3 ion channel function in Natural Killer cells from long COVID patients Etianne Martini Sasso, Natalie...
...https://www.s4me.info/threads/investigation-into-the-restoration-of-trpm3-ion-channel-activity-in-post-covid-19-sasso-marshall-gradisnik-et-al-2...
...this has been posted by ME Research UK https://www.meresearch.org.uk/trpm3-dysfunction-in-me-cfs-and-the-potential-role-of-low-dose-naltrexone-ldn/
...illuminates this pattern than Sonja Marshall-Gradisnuk’s work with TRPM3 ion channels at Griffith University in Australia over the past 8...
...Medicine Potential pathophysiological role of the ion channel TRPM3 in ME/CFS and the therapeutic effect of low-dose naltrexone - Lohn et al...
Full title: Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the...
...2024 Marshall-Gradisnik The finding of reduced function of TRPM3 channels needs to be replicated in ME/CFS (if only to find it isn't true and...
Summary of above - there are a lot of different forms of TRPM3, some don't even appear to work as ion channels. We don't yet know the functions...
Relevant to the TRPM3 work coming out of NCNED, Marshall-Gradisnik's lab. I've only half-read it so far, but it looks as though there are some...
...TRP channels are involved in numerous neurological disorders. TRPM3 belongs to the melastatin subfamily of TRP channels and represents a...
So, I guess the question I have is why hasn't the report of faulty TRPM3 in ME/CFS got more attention? The answer might be in forum threads on the...
...perspective, 2013 A slightly more recent paper From the paper: TRPM3 Endogenous agonists: Pregnenolone sulphate Wagner et al. (2008) [as...
The following paper has some background on TRPM3. But the paper is from 2008, and so surely more is known. I'd be interested to know why Sonya...
Discussion (There's quite a lot of typos in the paper) Conclusion So, I guess the authors are suggesting GWI is a channelopathy, as is...
Results GWI and control groups matched on age and BMI. No differences in full blood counts between the groups WHODAS Electrophysiology...
Methods So, it's looking as though it was done in the NCNED lab. Data about their symptoms was collected. Whole blood sample (We get told a...
Introduction
...I haven't read this paper yet and I forget if we have discussed the TRPM3 finding in ME/CFS and dismissed it. But why doesn't NCNED cooperate...
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