Here are the findings for ET-1 for the initial study cohort and the validation cohort
There do seem to be some people in the ME/CFS and PCS groups with values higher than the healthy controls.
The self-report has patients less sedentary, doing more light physical activity, a little more moderate physical activity, with both LC and HC doing a little vigorous physical activity. Not much difference between groups on objective actigraphy, but as @EndME points out above there is a large...
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The two striking things about the study are that:
1. This is the strongest evidence yet for endothelial dysfunction in patients, and is an important finding.
2. Potentially, dysfunction plays an important role in the illness, but the evidence for this is much weaker.
1. Important...
Endothelial dysfunction in ME/CFS patients
Sandvik MK, Sørland K, Leirgul E, Rekeland IG, Stavland CS, Mella O, Fluge Ø
Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study...
Transl Med
Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) Milan Haffke et al
Abstract
Background: Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of...
Here are my questions in full:
1. Is ME best understood as a form of cardiac dysfunction?
It is clear from the widespread symptoms that the disease involves systemic impairment. Can systemic hypoperfusion of tissues explain many or all of the symptoms of ME? If a pathogen or toxin which damages...
There was this paper from last year, Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome, 2020, Scherbakov et al
and back in 2011 there is this paywalled article, https://www.internationaljournalofcardiology.com/article/S0167-5273(11)01904-8/fulltext,
Large...
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