It really is pathetic, coming out just after Zhang et al. show important genetic causal links.
It seems they found a lot of negative messages about care and research - so they feel they need to send out a negative message about patients.
I don't see that as likely. How would they do it? There are no diffusion pathways from hypothalamus to the rest of the brain to transport soluble factors. Glia do not send action potentials. We are talking about cells maybe 50 microns across signalling to tissue fifteen centimetres away.
The...
Maybe it is a sign that if you have too dilute or non-specific a disease cohort you get nothing much. That would be helpful to confirm. It might partly explain why the first study of the Leeds biobank cohort produced little, despite having 2000 cases.
I have not looked at the latest information on this but the picture I have had is that yes circulating cytokines signal directly to CNS cell but those are probably very specialised cells I hypothalamus, where the blood brain barrier is a bit more open to protein diffusion or cells are...
Very fair points, Robert @RDP.
Some rogue cell population is hiding in plain sight here I think. We are just not used to the way it is tricking everything else.
It is increasingly my perception that the whole ethos of medicine in Western countries has changed - especially in the USA but also the UK (I am less in a position to judge for Europe). In the 1970s US medical literature was high quality. The textbooks were far more rigorous than in the UK...
It is all weird.
The daily steps seem much too consistent to me. My daily steps go up and down a lot more than that. Even if it was just the steps to the dining room and so on I would expect an odd day more and an odd day less.
The IgG 'with IVIG' seems to fall steadily, much as one might...
Indeed, but then that is true for depressive illness it seems. It is all a bit handwaving, especially when alcohol is supposed to be a cerebral depressant and yet it makes people sing rude songs and toboggan down the Main Street.
You have to remember that single dots on fluorescence nearly always include a proportion of artifactual signals (binding to dust or aggregates in the reagent). In the two pictures I have on file I don't see any significant signal in muscle cells. In the image without a vessel there are no dots...
Yes, absolutely. There is no way that free floating aggregated DNA would produce linear structures perpendicular to matrix and cell layering. In the 1980s I spent many hours sectioning and staining free floating aggregated DNA - when it was known as haematoxyphilic fibrinoid rather than some...
Either way I have absolutely no idea.
But remember that these are muscle biopsies, which are notorious for sampling problems.
I have seen just as puzzling results many times before.
The staining isn't amyloid of any known form so it is rather likely to be a red herring. It might be something...
I agree.
I think it is worth remembering that whereas we speculate that there might be more than one process under the roof of 'ME/CFS' there is no doubt whatsoever that 'depression' includes several completely different processes. To the extent that some of them make it hard to get to sleep and...
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