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  1. Jonathan Edwards

    ME/CFS as a biological information processing problem

    Acquired just means coming on later rather than congenital. It can be fully genetically programmed. It does not mean 'acquired from somewhere else'.
  2. Jonathan Edwards

    ME/CFS as a biological information processing problem

    Yes, I would see that as something quite different. And presumably dependent on neural signalling via action potentials.
  3. Jonathan Edwards

    Impact of COVID-19 & 2021 NICE Guidelines on Public Perspectives Toward ME/CFS: Twitter Analysis, 2025, Khakban et al (Jason Busse)

    It really is pathetic, coming out just after Zhang et al. show important genetic causal links. It seems they found a lot of negative messages about care and research - so they feel they need to send out a negative message about patients.
  4. Jonathan Edwards

    ME/CFS as a biological information processing problem

    I don't see that as likely. How would they do it? There are no diffusion pathways from hypothalamus to the rest of the brain to transport soluble factors. Glia do not send action potentials. We are talking about cells maybe 50 microns across signalling to tissue fifteen centimetres away. The...
  5. Jonathan Edwards

    Genome-wide Association Study of Long COVID, 2023, Lammi et al.

    Maybe it is a sign that if you have too dilute or non-specific a disease cohort you get nothing much. That would be helpful to confirm. It might partly explain why the first study of the Leeds biobank cohort produced little, despite having 2000 cases.
  6. Jonathan Edwards

    ME/CFS as a biological information processing problem

    I have not looked at the latest information on this but the picture I have had is that yes circulating cytokines signal directly to CNS cell but those are probably very specialised cells I hypothalamus, where the blood brain barrier is a bit more open to protein diffusion or cells are...
  7. Jonathan Edwards

    Itaconate modulates immune responses via inhibition of peroxiredoxin 5, 2025, Tomas Paulenda et al

    Very fair points, Robert @RDP. Some rogue cell population is hiding in plain sight here I think. We are just not used to the way it is tricking everything else.
  8. Jonathan Edwards

    Open Norway: Study of Daratumumab Injections for Patients with Moderate to Severe Chronic Fatigue Syndrome, 2025

    It still does not make sense and you would not get the wild fluctuations - they would be averaged out.
  9. Jonathan Edwards

    Comparing DNA Methylation Landscapes in Peripheral Blood from [ME/CFS] and Long COVID Patients, 2025, Peppercorn et al

    I agree. Run this sort of study again with a bit more finesse and we might see something very interesting.
  10. Jonathan Edwards

    Comparing DNA Methylation Landscapes in Peripheral Blood from [ME/CFS] and Long COVID Patients, 2025, Peppercorn et al

    Caramba!!! Always nice to capitalise on a picked cherry. But it is nice nevertheless.
  11. Jonathan Edwards

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    I looked up 'those who think bad about others: quotes' The best one is "Fake people always think others are fake"
  12. Jonathan Edwards

    AGA Clinical Practice Update on GI Manifestations and Autonomic or Immune Dysfunction in Hypermobile Ehlers-Danlos Syndrome: Expert Review 2025 Harris

    It is increasingly my perception that the whole ethos of medicine in Western countries has changed - especially in the USA but also the UK (I am less in a position to judge for Europe). In the 1970s US medical literature was high quality. The textbooks were far more rigorous than in the UK...
  13. Jonathan Edwards

    Open Norway: Study of Daratumumab Injections for Patients with Moderate to Severe Chronic Fatigue Syndrome, 2025

    It is all weird. The daily steps seem much too consistent to me. My daily steps go up and down a lot more than that. Even if it was just the steps to the dining room and so on I would expect an odd day more and an odd day less. The IgG 'with IVIG' seems to fall steadily, much as one might...
  14. Jonathan Edwards

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Indeed, but then that is true for depressive illness it seems. It is all a bit handwaving, especially when alcohol is supposed to be a cerebral depressant and yet it makes people sing rude songs and toboggan down the Main Street.
  15. Jonathan Edwards

    ME/CFS as a biological information processing problem

    You have to remember that single dots on fluorescence nearly always include a proportion of artifactual signals (binding to dust or aggregates in the reagent). In the two pictures I have on file I don't see any significant signal in muscle cells. In the image without a vessel there are no dots...
  16. Jonathan Edwards

    ME/CFS as a biological information processing problem

    Yes, absolutely. There is no way that free floating aggregated DNA would produce linear structures perpendicular to matrix and cell layering. In the 1980s I spent many hours sectioning and staining free floating aggregated DNA - when it was known as haematoxyphilic fibrinoid rather than some...
  17. Jonathan Edwards

    ME/CFS as a biological information processing problem

    Either way I have absolutely no idea. But remember that these are muscle biopsies, which are notorious for sampling problems. I have seen just as puzzling results many times before. The staining isn't amyloid of any known form so it is rather likely to be a red herring. It might be something...
  18. Jonathan Edwards

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    I agree. I think it is worth remembering that whereas we speculate that there might be more than one process under the roof of 'ME/CFS' there is no doubt whatsoever that 'depression' includes several completely different processes. To the extent that some of them make it hard to get to sleep and...
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