Cytokine profiles in patients with Q fever fatigue syndrome, 2019, Raijmakers et al

Andy · Feb 2, 2019

Abstract
Background
Q fever fatigue syndrome (QFS) is a state of prolonged fatigue following around 20% of acute Q fever cases. It is thought that chronic inflammation plays a role in its aetiology. To test this hypothesis we measured circulating cytokines and the exvivo cytokine production in patients with QFS and compared to various control groups.

Materials/methods
Peripheral blood mononuclear cells (PBMCs), whole blood, and serum were collected from 20 QFS patients, 19 chronic fatigue syndrome (CFS) patients, 19 Q fever seropositive controls, and 25 age- and sex-matched healthy controls. Coxiella-specific ex-vivo production of tumor necrosis factor (TNF)α, interleukin (IL)-1β, IL-6, and interferon (IFN) was measured, together with a total of 92 circulating inflammatory proteins.

Results
PBMCs of QFS patients produced more IL-6 (P = 0.0001), TNFα (P = 0.0002), and IL-1β (P = 0.0005) than the various control groups when stimulated with Coxiella antigen. QFS patients had distinct differences in circulating inflammatory markers compared to the other groups, including higher concentrations of circulating IL-6 and IFNγ.

Conclusion
QFS patients showed signs of chronic inflammation compared to asymptomatic Q fever seropositive controls, CFS patients, and healthy controls, of which the monocyte-derived cytokines TNFα, IL-1β, and especially IL-6, are likely crucial components.
Click to expand...

Paywalled at https://www.journalofinfection.com/article/S0163-4453(19)30027-1/fulltext

Trish · Feb 2, 2019

Just reminding myself what Q fever is.

Q fever, also called query fever, is a bacterial infection caused by the bacteria Coxiella burnetii. The bacteria are most commonly found in cattle, sheep, and goats around the world. Humans typically get Q fever when they breathe in dust that was contaminated by infected animals.
Click to expand...

Log in or Sign up

Cytokine profiles in patients with Q fever fatigue syndrome, 2019, Raijmakers et al

Andy Committee Member

Trish Moderator Staff Member

Share This Page

Log in or Sign up

Cytokine profiles in patients with Q fever fatigue syndrome, 2019, Raijmakers et al

Andy Committee Member

Trish Moderator Staff Member

Share This Page

Useful Searches