News from PrecisionLife Ltd.

https://precisionlife.com/news-and-events/biohackathon-mecfs

https://twitter.com/user/status/1759946318246482341

 

ME Research UK is excited to be involved in a BioHackathon at University College London this Friday, organised by Precision Life (@precisionlifeAI) where @ucl researchers will explore 3 key ME/CFS questions. Read more: tinyurl.com/cf44z9ay #MECFS #MyalgicEncephalomyelitis

 

Really cheered me up to see all these young people show up for us..

 

Tweet from PrecisionLife

"We're delighted to share the progress being made in the #MetX research study. PrecisionLife and @MetrodoraInst have begun sharing the first results with #MECFS and #LongCOVID participants - bridging from Biobank Analysis to Bedside in record time.

https://precisionlife.com/news-and-...e-first-insights-with-metx-study-participants"

 

From link to "More about our ME/CFS research" at the bottom:

"In over 30 years of global research into the disease, not a single replicable genetic finding had been reported until now.

We have for the first time identified some of the different genetic mechanisms causing ME/CFS and used this to stratify patients.

We’re currently replicating our results in a much larger, better characterized patient population, using thee DecodeME study data as part of the LOCOME (Long Covid and ME) grant supported by Innovate UK.

PrecisionLife is now conducting research to:

1. Validate simple saliva/blood genotyping tests for ME/CFS and long COVID
2. Identify actively protective biology that may prevent people getting ME or help them to recover
3. Identify and validate drug repurposing candidates that may be able to treat ME patients

Here, we've collated links to papers, posters, videos and blogs, about our recent ME/CFS and long COVID research."

Papers they cite (links to threads):

Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis, 2022, Das et al

Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis, 2023, Taylor et al

 

Alright, tell me why this is too good to be true...


Okay done a bit more reading before I hit post. This looks genuinely promising to my layman's eye. Did anyone catch the part in one of their maps where they claim to have identified 7 prospective drugs for repurposing?

 

PrecisionLife and Metrodora Foundation announce confirmation of key genetic findings for long COVID across diverse populations

Results reproduce PrecisionLife’s previously identified long COVID genetic associations to provide compelling evidence for new precision diagnostics and treatments

OXFORD, UK and SALT LAKE CITY, UT – 26 February 2025

• 45 out of 51 (88%) of genes identified by PrecisionLife in its previous UK study were confirmed to also be associated with long COVID in an independent US cohort
• 11 out of 13 genes for which drug repurposing candidates have been identified were reproduced, encouraging their rapid validation in clinical trials
• The findings highlight the biology underlying long COVID, with potential for refining diagnostic criteria, the discovery of more accurate diagnostic tools, and exploring therapeutic targets for long COVID, ME/CFS and related chronic conditions.
• Demonstrates the unique capability of AI-led combinatorial analytics for understanding the genetic mechanisms underpinning complex diseases affecting multiple systems in the body

LINK

 

I believe it’s this paper:
https://www.s4me.info/threads/repro...-uk-patient-cohorts-2025-sardell-et-al.42529/

 

Just wanted to highlight this document where Precision Life outline their plans regarding clinical trials and next steps. It seems extremely optimistic and obviously they are a business, but it's the clearest explanation of what they plan that I've found.

The stuff about protective biology is particularly intriguing...

Really interested to see if their findings replicate in DecodeME

https://precisionlife.com/hubfs/Lon...by PrecisionLife.pdf?hsCtaAttrib=186733826981

 

Looks like they have already replicated some results using at least some of the DecodeME data.

 

Ooh...

 

That sounds like good news! Missed that bit. Hopefully they can publish something soon.

 

Spill the beans on the 9 drugs!?

The fact that they say the nine drugs are safe is not encouraging.

If they said it was something dangerous like this https://en.wikipedia.org/wiki/Melarsoprol, I’d be more inclined to believe it.

I’m only being partially facetious.

 

”We’re running clinical trials in the US, recruiting 1,000 ME and long COVID patients to clinically validate these new diagnostic & therapeutic options”


Anyone has any idea where we could find information about these clinical trials?

 

I think this has the info, including how to join: https://www.metrodorainstitute.co/metxstudy

 

It also says on the information about the MELO study page

'This is a low-risk study with no intervention or treatment. Sample collection, using a cheek swab, involves minimal to no physical risk and no research related injuries are expected.'

Which is interesting considering they are talking about it elsewhere like participants will be given one of these 9 drugs as part of the study. But perhaps thats like part 2 after they validate the diagnostic.

It's all a bit vague.


P.s. don't know how to make text into the yellow quotes if not quoting direct from forum haha

 

I know what you mean! I sort of feel like that but perhaps it is an irrational feeling?

Plus safe is a relative term in medical drug lexicon. A lot of stuff can be 'safe' but have quite unpleasant side effects.

 

Select the text, then press the button highlighted below, then "Quote" in the dropdown. Or press the button first, and paste the text in between the [ QUOTE] and [ /QUOTE]