Nothing specific but I am optimistic that enough good people are focused on the problem now that we will get some answers about mechanisms...
Multiple sclerosis (MS) has long been considered a CD4 T-cell disease, primarily because of the findings that the strongest genetic risk for MS is...
Fair enough but I think the context was sampling allowing herd immunity from infection? I didn't look at it in detail but it seemed a bit tone...
I would be depressed if someone diagnosed me with hEDS and sent me to a rehab centre where they did mindless research. Moreover, it would be a...
At the cost of schoolfriends of mine being paralysed and no doubt others who might have been schoolfriends of mine dying beforehand.
Except that MS is a B cell disease - as at last shown with ocrelizumab twenty years late. Like RA, it has always been promoted as a T cell disease...
MEPedia: 'Dr. Friedman has served on the Board of the International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME)'...
This is a rather peculiar statement. I wonder who it is aimed at ! The United States has produced the highest number of ME/CFS research...
Don't worry, @paulendat you can easily sell me some shares in itaconatePLC. But yes, we need to know where and when and we need the whole picture....
It is very doable. The question is why, if it actually works, it has not been translated into treatment. It is harder to see how it work for B...
I have visions of knock-in mice with a super active happiness gene allele. Whiskers twitching all over the place.
For about twenty five years friends of mine have talked of manufacturing 'bispecific' monoclonal antibody drugs that in theory are very clever but...
Those do not seem to me to be likely to pick out PEM. Being tired after exertion is very nonspecific and if someone is feeling generally tired...
I don't think thiamazole has any effect on the autoimmune process that triggers the hyperthyroidism, it just poisons the thyroid enough to stop it...
No, I think the concept is a perfectly good one. A thought is about something - about a dog or a movement of a tree in the wind. The problem has...
One thing I have been wondering about recently is what philosophers call the problem of 'intentionality'. This has nothing to do with intent or...
Yes, it could. I think I was responding to what looked like an assumption that autoimmunity required some special T cell memory in the article...
I may be wrong but it seems to me that you need a clear separation between people supplying funding and people benefitting from funding. This...
Except that it does happen. To me the research programme that made the quantum shift to real science for ME/CFS was that of Oystein Fluge and Olav...
Yes B cells require T cell help but as far as we know they get help from T cells recognising foreign antigens, as they should. The problem lies in...
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