I’m currently pondering whether to do a whole genome sequence test or not and I am hoping to solicit some educated comments. here’s the situation. I live in the USA and my health insurance is Medicare which is the government backed insurance system. My consulting MD is a neurologist at an University related teaching hospital and who keeps up with his field closely (especially genetics) and is a good communicator. For the last year and a half my doc has been ordering genetic testing from this company, Invitae (https://www.invitae.com/en), which has genetic panels you can order free of charge to me under the Medicare system. We have run many panels; neuromuscular, immunological, mitochondrial and some for specific diseases. none of these have popped up anything significant. so at my last consult I had I asked my doc why we don’t just run a whole genome panel and he said that was something to consider at this point. The issue is that Medicare will not currently pay for a whole genome sequence, so I have to self pay. He uses the company Variantyx ( https://variantyx.com ) because they have the least expensive testing regime. I have been told the cost will be $1000 for the test and report. Invitae updates and adds to their panels frequently and has excellent customer service in my experience, so we can rerun these panels every year for no cost to me. I really have not been able to find much information about the benefits of doing a whole genome sequence at this point. I had a consult with a geneticist who works with my doc, but it really was no help. So, any opinions on the current state of the art whole genome sequencing being beneficial in the clinic setting? right now I am leaning towards delaying the WGS indefinitely..