I've been wishing for ages that someone would write a review paper reviewing the established biomedical differences between ME/CFS and deconditioning. My impression is that a lot is known about the biology of deconditioning, and that the BPS school didn't bother to read any of it before coming up with their idea that ME/CFS was simply deconditioning plus 'false illness beliefs'. Wouldn't it have been great if we'd had a review paper before PACE had even got funded? One that we could have pointed to to squash that trial before it even got started and wasted £5 million? Wouldn't it be great if now, every time somebody said, 'You ME patients are just deconditioned,' we could point to such a paper? Do you agree? What papers do we wish existed, that could be written now based on research that's already out there? Or perhaps on data that's already sitting in the drawer? [Edit: My list originally included, 'Or that could be easily got?' but that caused confusion and now Sean has started a new thread for research that would require new data, here.] Should we make a list, and (as S4ME) promote it to researchers? What are the missing papers?