1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 18th March 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

The Role of Cell Adhesion & Cytoskeleton Dynamics in the Pathogenesis of the Ehlers-Danlos Syndromes & Hypermobility Spectrum Disorders, 2021, Malek

Discussion in ''Conditions related to ME/CFS' news and research' started by Andy, Apr 22, 2021.

  1. Andy

    Andy Committee Member

    Messages:
    21,808
    Location:
    Hampshire, UK
    The Ehlers-Danlos syndromes (EDS) are a group of 13 disorders, clinically defined through features of joint hypermobility, skin hyperextensibility, and tissue fragility. Most subtypes are caused by mutations in genes affecting the structure or processing of the extracellular matrix (ECM) protein collagen. The Hypermobility Spectrum Disorders (HSDs) are clinically indistinguishable disorders, but are considered to lack a genetic basis. The pathogenesis of all these disorders, however, remains poorly understood. Genotype-phenotype correlations are limited, and findings of aberrant collagen fibrils are inconsistent and associate poorly with the subtype and severity of the disorder. The defective ECM, however, also has consequences for cellular processes. EDS/HSD fibroblasts exhibit a dysfunctional phenotype including impairments in cell adhesion and cytoskeleton organization, though the pathological significance of this has remained unclear. Recent advances in our understanding of fibroblast mechanobiology suggest these changes may actually reflect features of a pathomechanism we herein define.

    This review departs from the traditional view of EDS/HSD, where pathogenesis is mediated by the structurally defective ECM. Instead, we propose EDS/HSD may be a disorder of membrane-bound collagen, and consider how aberrations in cell adhesion and cytoskeleton dynamics could drive the abnormal properties of the connective tissue, and be responsible for the pathogenesis of EDS/HSD.

    Open access, https://www.frontiersin.org/articles/10.3389/fcell.2021.649082/full
     
  2. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    Messages:
    13,267
    Location:
    London, UK
    Thes people work on the mechanics of fibroblasts and want hEDS/HSD (whatever that might be) to be a disorder of the mechanics of fibroblasts. It looks totally implausible to me. The mechanical property of being able to bend your elbow backwards by 15 degrees cannot be due to the mechanics of fibroblasts. It must be the collagen.
     
    TrixieStix, DokaGirl, FMMM1 and 3 others like this.
  3. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Messages:
    3,819
    Location:
    Australia
    What you are saying is not mutually exclusive. In principle, defects of the fibroblasts can lead to defects in the collagen networks.
     
    Sarah94 and DigitalDrifter like this.
  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    Messages:
    13,267
    Location:
    London, UK
    Defects in the fibroblasts by definition are responsible for the defects in the collagen network but that is not what they are suggesting as far as I can see.
     
    alktipping, TrixieStix and FMMM1 like this.
  5. Andy

    Andy Committee Member

    Messages:
    21,808
    Location:
    Hampshire, UK
    Snow Leopard and Binkie4 like this.
  6. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    Messages:
    13,267
    Location:
    London, UK
    I am afraid that this reads like a computer-generated word salad based on popular memes about 'hEDS'.

    Real scientists are not 'excited to share'. They let their data speak for itself.
     
    alktipping, FMMM1, TrixieStix and 3 others like this.

Share This Page