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The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications, 2021, Breikaa and Lilly

Discussion in 'Epidemics (including Covid-19, not Long Covid)' started by wastwater, Dec 8, 2021.

  1. wastwater

    wastwater Senior Member (Voting Rights)

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    https://www.frontiersin.org/articles/10.3389/fcvm.2021.681948/full
    The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

    Abstract

    COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.


    quote
    The first evidence that demonstrated Notch pathway-viral interactions was reported for the Epstein-Barr virus

    I have a PITX2 notch3 (cadasil) interaction
     
    Last edited by a moderator: Dec 26, 2021
  2. wastwater

    wastwater Senior Member (Voting Rights)

    Messages:
    347
    Last edited by a moderator: Dec 26, 2021
    Peter Trewhitt likes this.
  3. wastwater

    wastwater Senior Member (Voting Rights)

    Messages:
    347
    Would a skin biopsy show anything
     
    Peter Trewhitt likes this.
  4. wastwater

    wastwater Senior Member (Voting Rights)

    Messages:
    347
    I think this may effect the diameter of blood vessels could that be important
     

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