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The body's own bathroom scales—a new understanding of obesity

Discussion in 'Health News and Research unrelated to ME/CFS' started by Helen, Dec 27, 2017.

  1. Helen

    Helen Senior Member (Voting Rights)

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    "Researchers at Sahlgrenska Academy, University of Gothenburg, Sweden, have found evidence for the existence of an internal body weight sensing system. This system operates like bathroom scales, registering body weight and thereby fat mass. More knowledge about the sensing mechanism could lead to a better understanding of the causes of obesity as well as new anti-obesity drugs."

    Abstract

    Subjects spending much time sitting have increased risk of obesity but the mechanism for the antiobesity effect of standing is unknown.

    We hypothesized that there is a homeostatic regulation of body weight. We demonstrate that increased loading of rodents, achieved using capsules with different weights implanted in the abdomen or s.c. on the back, reversibly decreases the biological body weight via reduced food intake.

    Importantly, loading relieves diet-induced obesity and improves glucose tolerance. The identified homeostat for body weight regulates body fat mass independently of fat-derived leptin, revealing two independent negative feedback systems for fat mass regulation.

    It is known that osteocytes can sense changes in bone strain. In this study, the body weight-reducing effect of increased loading was lost in mice depleted of osteocytes.

    We propose that increased body weight activates a sensor dependent on osteocytes of the weight-bearing bones. This induces an afferent signal, which reduces body weight. These findings demonstrate a leptin-independent body weight homeostat (“gravitostat”) that regulates fat mass.

    Full study:
    Body weight homeostat that regulates fat mass independently of leptin in rats and mice
    http://www.pnas.org/content/early/2017/12/19/1715687114.full

    Article in media:
    https://medicalxpress.com/news/2017-12-body-bathroom-scalesa-obesity.html
     
  2. Wonko

    Wonko Senior Member (Voting Rights)

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    So rats that are forced to carry around weights lose weight? I wonder if this works with researchers? Strap half a dozen 20kg plates to a researcher for a few months and see what happens........
     
    Trish, Helen and Invisible Woman like this.

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