PEM has become a mandatory symptom in many CFS guidelines, so I would expect that there is plenty of data of monitored patients during the malaise/fatigue interval because this is when the disease's mechanism of action is amplified and certain biomarkers should stick out and be clearer. Maybe I'm not using the correct search terms, but I can't find anything. Fortunately, @Forbin referenced this study in another post (10.1016/j.jpain.2009.06.003), which is a gene expression monitoring, but it's not primarily what I'm looking for. I'm looking for typical metabolic profiles, blood biomarkers, and neurotransmitters over the course of the malaise. Maybe you have found something like this. I would appreciate any comments.