Sleep deprivation of some kind seems a very common symptom for PwME, and it can have significant consequences all of its own, depending on severity. Sleep deprivation must be a consequence of many illnesses. My wife never really gets a healthy refreshing night's sleep, no matter how many hours she is asleep. Has any research (good, well controlled, well intentioned research that is) ever been done to separate out the impact of the sleep deprivation alone for PwME, from all the other illness components which contribute to the misery for PwME. My wife certainly feels that the never-ending lack of good refreshing sleep is a major contributor to her problems.