There was a little bit of discussion about this when people were tweeting about it from the conference but I'm watching the conference DVD now and this seems quite striking. I hope the biomedical brains here (such as @Jonathan Edwards!) might weigh in on how to think about it. Davis reported that the gene expression in PWME is very similar to that in trypanosome (a blood parasite) and other parasite infection, compared with nearly 100,000 other disease signatures. His team is currently making DNA probes against all known trypanosomes and parasites. He said that in West Africa, you can detect trypanosomes easily in the blood but rarely see them in infections in East Africa even though they're present. He wonders if we all have a trypansome infection or whether having a trypanosome infection is one route to ME. If the latter, I don't understand why EBV etc. wouldn't give the same ME signature because we know from the Dubbo study that EBV is one of several viral routes to ME. Anybody with relevant expertise care to weigh in? Should we all be rushing out to get ourselves tested for trypanosomes (although if we've got the East African version, it wouldn't get picked up, presumably)?