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Risk factors for long covid in previously hospitalised children using the ISARIC follow-up protocol: A prospective cohort study, 2021, Osmanov et al

Discussion in 'Long Covid research' started by Andy, Jul 3, 2021.

  1. Andy

    Andy Committee Member

    Messages:
    21,810
    Location:
    Hampshire, UK
    Abstract

    Background The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.

    Methods This is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.

    Findings 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3–15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and “12–18 years” (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).

    Interpretation A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

    Open access, https://erj.ersjournals.com/content/early/2021/06/10/13993003.01341-2021
     
  2. Peter Trewhitt

    Peter Trewhitt Senior Member (Voting Rights)

    Messages:
    3,636
    Such a shame that there don’t seem to be many/any prospective studies.

    Certainly in the UK now is the time for such studies as the delta variant seems to have been given free reign in relation to children and young adults.
     
    Hutan, alktipping and Andy like this.
  3. Hutan

    Hutan Moderator Staff Member

    Messages:
    26,522
    Location:
    Aotearoa New Zealand
    A study from Russia. Interesting that being female was not found to be associated with increased risk of persistent symptoms in this pediatric prospective study, whereas being older and having a history of allergies was.
     
    Last edited: Jul 4, 2021
    Wyva, Amw66, Andy and 3 others like this.

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