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Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies. Gunning et al 2019

Discussion in ''Conditions related to ME/CFS' news and research' started by John Mac, Sep 9, 2019.

  1. John Mac

    John Mac Senior Member (Voting Rights)

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    https://www.ahajournals.org/doi/10.1161/JAHA.119.013602
     
    Last edited: Sep 9, 2019
  2. ahimsa

    ahimsa Senior Member (Voting Rights)

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    Thanks for posting. I'm hoping this discovery (and future studies) will eventually be helpful for the subset of ME/cfs patients who have POTS, NMH or some other sort of Orthostatic Intolerance.
     
    Yessica, Milo, alktipping and 4 others like this.
  3. ahimsa

    ahimsa Senior Member (Voting Rights)

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    Article about this study by Science Daily - https://www.sciencedaily.com/releases/2019/09/190909081756.htm
    Edited to add a quote from the article
     
    OverTheHills, Yessica, Amw66 and 10 others like this.
  4. OverTheHills

    OverTheHills Senior Member (Voting Rights)

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    I look to smarter people than me for guidance on the importance of this.

    As a pwME with POTS, to me this looks like it could be very useful indeed. I know that talk of subgrouping gives rise to worries about throwing the rest/others under the bus, but it might get a large group of patients a medical speciality 'home' and change attitudes from some medical professionals. POTS and ME are both poorly understood at the moment and have large symptom overlap. I dont really care at the moment which labels doctors attach, as long as they provide sensible advice/ symptom relief/treatment one day.

    Is this a robust study or flaky?
     
  5. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    It does not look like a rigorous scientific study to me. Almost nothing is said about controls.

    In general these antibodies tend to turn up I almost any situation people look for them in. Anti-muscarinic receptor antibodies have become a bit of a joke in neuro-immunology.

    From my perspective if researchers are not prepared to describe work in a way that allows others to assess it meaningfully then they cannot expect it to be taken seriously.
     
    TrixieStix and OverTheHills like this.
  6. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    Dysautonomia International have been funding studies in this area, but the researchers in Oaklahoma carrying out the work with their funding had doubts about the test and spent a long time figuring out that norepinephrine in serum samples can artificially elevate a1AR and ß1AR activity. It's not clear that the Cell Trend ELISA tests used in the paper of this thread account for that fact.

    This study has controls @Jonathan Edwards (37 patients, 61 controls)

    Paper : A functional cell-based bioassay for assessing adrenergic autoantibody activity in postural tachycardia syndrome (20 June 2019)
    https://www.sciencedirect.com/scien...7hAiZv6YmgsbJhRPIEqKV-6fey-R3b7zdGFAHFVEPuxkY
    This was the commentry on the paper and work posted by Dysautonomia International in June
    s4me thread on this paper
    https://www.s4me.info/threads/a-fun...al-tachycardia-syndrome-2019-raj-et-al.10162/
     
    Last edited: Sep 19, 2019
    Dolphin, Aroa and OverTheHills like this.

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