PACE team response shows a disregard for the principles of science, 2017, Edwards

Edwards J. PACE team response shows a disregard for the principles of science. Journal of Health Psychology. 2017;22(9):1155-1158. doi:10.1177/1359105317700886

Abstract

The PACE trial of cognitive behavioural therapy and graded exercise therapy for chronic fatigue syndrome/myalgic encephalomyelitis has raised serious questions about research methodology.

An editorial article by Geraghty gives a fair account of the problems involved, if anything understating the case. The response by White et al. fails to address the key design flaw, of an unblinded study with subjective outcome measures, apparently demonstrating a lack of understanding of basic trial design requirements.

The failure of the academic community to recognise the weakness of trials of this type suggests that a major overhaul of quality control is needed.

(This is a commnentary on: White PD, Chalder T, Sharpe M, et al. Response to the editorial by Dr Geraghty. Journal of Health Psychology. 2017;22(9):1113-1117. doi:10.1177/1359105316688953 )

 

See also: Tuller D. Once again, the PACE authors respond to concerns with empty answers. Journal of Health Psychology. 2017;22(9):1118-1122. doi:10.1177/1359105317703788

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