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Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV‐2, 2022, Pliss et al

Discussion in 'Long Covid research' started by SNT Gatchaman, Jul 29, 2022.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV‐2
    Artem Pliss, Andrey N. Kuzmin, Paras N. Prasad, Supriya D. Mahajan

    The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is increasingly attributed to
    mitochondrial dysfunction of brain microglia cells. However, the changes in biochemical content of mitochondria that drive the progression of neuro-COVID remain poorly understood.

    Here we introduce a Raman microspectrometry approach that enables the molecular profiling of single cellular organelles to characterize the mitochondrial molecular makeup in the infected microglia cells. We found that microglia treated with either spike protein or heat-inactivated SARS-CoV-2 trigger a dramatic reduction in mtDNA content and an increase in phospholipid saturation levels. At the same time, no significant changes were detected in Golgi apparatus
    and in lipid droplets, the organelles that accommodate biogenesis and storage of lipids.

    We hypothesize that transformations in mitochondria are caused by increased synthesis of reactive oxygen species in these organelles. Our findings call for the development of mitochondria-targeted therapeutic approaches to limit neuropathology associated with SARS-CoV-2.

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  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Location:
    Aotearoa New Zealand
     
  3. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

    Messages:
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    Location:
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    Last edited: Jul 29, 2022

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