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Microparticles in the blood of patients with SLE [Lupus]: Size, content of mitochondria and role in circulating immune complexes, 2019, Mobarrez et al

Discussion in 'Other health news and research' started by Andy, May 20, 2019.

  1. Andy

    Andy Committee Member

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    21,810
    Location:
    Hampshire, UK
    Paywall, https://www.sciencedirect.com/science/article/pii/S089684111930099X
    Sci hub, https://sci-hub.se/10.1016/j.jaut.2019.05.003
     
    ScottTriGuy and MEMarge like this.
  2. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    13,273
    Location:
    London, UK
    The methodology in terms of numbers studied is peculiar. It looks as if they did two different studies. The abstract gives no hard figures which it should.

    We would expect SLE patients to have more microparticles than controls and probably including bits of mitochondria because a central feature of lupus is failure to clear debris from circulation by complement. The resulting immune complexes are generally thought to be the cause of nephritis and some other features.
     

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